Regulation of substance P in adult rat sympathetic ganglia

John A. Kessler*, Ira B. Black

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Factors regulating the putative peptide neurotransmitter, substance P, were examined in the adult rat sympathetic superior cervical ganglion (SCG). Surgical section of the preganglionic nerves resulted in a 55% increase in ganglion content of SP-like immunoreactivity (subsequently termed SP). Treatment with chlorisondamine, which blocks nicotinic ganglionic transmission, also increased SP, reproducing the effects of decentralization. Conversely, treatment with phenoxybenzamine, which reflexly increases sympathetic activity, reduced ganglion SP. Axotomy of the postganglionic nerves did not alter ganglion SP. Finally, treatment of rats as neonates with 6-hydroxydopamine, which selectively destroys principal ganglion neurons, profoundly decreased SP in the adult SCG. Our observations suggest that impulse activity of preganglionic nerves decreases ganglion SP in principal ganglion neurons through a transsynaptic process. Viewed in conjunction with previous work, our studies suggest that transsynaptic stimulation has opposite effects on SP and noradrenergic transmitter characters in the SCG.

Original languageEnglish (US)
Pages (from-to)182-187
Number of pages6
JournalBrain research
Volume234
Issue number1
DOIs
StatePublished - Feb 18 1982

Keywords

  • 6-hydroxydopamine
  • chlorisondamine
  • neuropeptide
  • phenoxybenzamine
  • superior cervical ganglion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Regulation of substance P in adult rat sympathetic ganglia'. Together they form a unique fingerprint.

Cite this