Regulation of the steroidogenic acute regulatory protein gene expression: Present and future perspectives

Pulak R. Manna, Matthew T. Dyson, Douglas M. Stocco*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

187 Scopus citations

Abstract

Steroid hormones are synthesized in the adrenal gland, gonads, placenta and brain and are critical for normal reproductive function and bodily homeostasis. The steroidogenic acute regulatory (StAR) protein regulates the rate-limiting step in steroid biosynthesis, i.e. the delivery of cholesterol from the outer to the inner mitochondrial membrane. The expression of the StAR protein is predominantly regulated by cAMP-dependent mechanisms in the adrenal and gonads. Whereas StAR plays an indispensable role in the regulation of steroid biosynthesis, a complete understanding of the regulation of its expression and function in steroidogenesis is not available. It has become clear that the regulation of StAR gene expression is a complex process that involves the interaction of a diversity of hormones and multiple signaling pathways that coordinate the cooperation and interaction of transcriptional machinery, as well as a number of post-transcriptional mechanisms that govern mRNA and protein expression. However, information is lacking on how the StAR gene is regulated in vivo such that it is expressed at appropriate times during development and is confined to the steroidogenic cells. Thus, it is not surprising that the precise mechanism involved in the regulation of StAR gene has not yet been established, which is the key to understanding the regulation of steroidogenesis in the context of both male and female development and function.

Original languageEnglish (US)
Pages (from-to)321-333
Number of pages13
JournalMolecular human reproduction
Volume15
Issue number6
DOIs
StatePublished - 2009

Keywords

  • AKAP
  • CAMP signaling
  • StAR gene expression
  • Transcription
  • Translation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Molecular Biology
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Regulation of the steroidogenic acute regulatory protein gene expression: Present and future perspectives'. Together they form a unique fingerprint.

Cite this