Regulation of voltage-dependent Ca2+ channels of neuronal cells by chronic changes in membrane potential

Eleanor M. Delorme, Richard McGee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The regulation of voltage-dependent Ca2+ channels by chronic changes in membrane potential was studied by measuring the binding of [3H]nitrendipine to membranes from PC12 pheochromocytoma cells. Depolarization of the cells by elevation of extracellular K+ caused up to a 45% loss of [3H]nitrendipine binding sites within 4 days without any change in Kd. Repolarization of the cells caused a return to control binding within 1-2 days, showing that either decreases or increases in membrane potential can cause reversible changes in [3H]nitrendipine binding sites.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalBrain research
Issue number1
StatePublished - Nov 5 1986


  • Chronic depolarization
  • PC12 cell
  • Voltage-dependent calcium channel

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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