Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary

Jaesook Roh*, Jeehyeon Bae, Kangseok Lee, Kelly Mayo, Lonnie Shea, Teresa K. Woodruff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage.

Original languageEnglish (US)
Pages (from-to)1451-1454
Number of pages4
JournalFertility and Sterility
Volume91
Issue number4 SUPPL.
DOIs
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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