Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary

Jaesook Roh; Jeehyeon Bae; Kangseok Lee; Kelly Mayo; Lonnie Shea; Teresa K. Woodruff

doi:10.1016/j.fertnstert.2008.07.012

Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the immature mouse ovary

Jaesook Roh^*, Jeehyeon Bae, Kangseok Lee, Kelly Mayo, Lonnie Shea, Teresa K. Woodruff

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage.

Original language	English (US)
Pages (from-to)	1451-1454
Number of pages	4
Journal	Fertility and Sterility
Volume	91
Issue number	4 SUPPL.
DOIs	https://doi.org/10.1016/j.fertnstert.2008.07.012
State	Published - Apr 1 2009

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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abstract = "This study investigated the regulation of Wilms' tumor gene (WT1) in the ovary by nerve growth factor and FSH to better understand signals that initiate early follicular growth. Nerve growth factor showed a direct stimulatory effect on endogenous expression of WT1, whereas FSH attenuated basal and nerve growth factor-stimulated WT1 protein expression, which most likely depended on FSH responsiveness according to the follicle growth stage.",

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AU - Shea, Lonnie

AU - Woodruff, Teresa K.

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