Regulation of Wnt/β-catenin signaling by protein kinases

Esther M. Verheyen; Cara J. Gottardi

doi:10.1002/dvdy.22019

Regulation of Wnt/β-catenin signaling by protein kinases

Esther M. Verheyen, Cara J. Gottardi

Medicine, Pulmonary Division

Research output: Contribution to journal › Review article › peer-review

142 Scopus citations

Abstract

The Wnt/β-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases.

Original language	English (US)
Pages (from-to)	34-44
Number of pages	11
Journal	Developmental Dynamics
Volume	239
Issue number	1
DOIs	https://doi.org/10.1002/dvdy.22019
State	Published - Jan 2010

Keywords

CKI
GSK3
Protein kinase
Wnt
β-catenin

ASJC Scopus subject areas

Developmental Biology

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10.1002/dvdy.22019

Cite this

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abstract = "The Wnt/β-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases.",

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Regulation of Wnt/β-catenin signaling by protein kinases

Abstract

Keywords

ASJC Scopus subject areas

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