Regulation of Wnt/β-catenin signaling by protein kinases

Esther M. Verheyen, Cara J. Gottardi

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations


The Wnt/β-catenin signaling pathway plays essential roles during development and adult tissue homeostasis. Inappropriate activation of the pathway can result in a variety of malignancies. Protein kinases have emerged as key regulators at multiple steps of the Wnt pathway. In this review, we present a synthesis covering the latest information on how Wnt signaling is regulated by diverse protein kinases.

Original languageEnglish (US)
Pages (from-to)34-44
Number of pages11
JournalDevelopmental Dynamics
Issue number1
StatePublished - Jan 2010


  • CKI
  • GSK3
  • Protein kinase
  • Wnt
  • β-catenin

ASJC Scopus subject areas

  • Developmental Biology


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