Regulatory effects of intrinsic IL-10 in IgG immune complex-induced lung injury

T. P. Shanley, H. Schmal, H. P. Friedl, M. L. Jones, P. A. Ward*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

IL-10 has regulatory effects in vitro on cytokine production by activated macrophages. In the IgG immune complex model of lung injury, exogenously administered IL-10 has been shown to suppress in vivo formation of TNF-α, up-regulation of vascular ICAM-1, neutrophil recruitment, and ensuing lung injury. In the current study, we sought to determine whether endogenous IL- 10 is playing a regulatory role in the lung inflammatory response. On the basis of lung mRNA and ELISA measurements, IL-10 induction was found during development of inflammation in the IgG immune complex model of lung injury. Blocking of IL-10 by Ab resulted in a 52% increase in lung vascular permeability, a 56% increase in TNF-α activity in bronchoalveolar lavage fluids, and a 47 to 48% increase in bronchoalveolar lavage neutrophils and lung myeloperoxidase content. These findings suggest that IL-10 is an important natural regulator of lung inflammatory injury after deposition of IgG immune complexes.

Original languageEnglish (US)
Pages (from-to)3454-3460
Number of pages7
JournalJournal of Immunology
Volume154
Issue number7
StatePublished - 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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