Regulatory properties of neuronal cdc2-like kinase

Zhong Qi, Damu Tang, Isao Matsuura, Ki Young Lee, Xujing Zhu, Qi Quan Huang, Jerry H. Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Neuronal cdc2-like kinase, nclk, is a heterodimer of cyclin dependent protein kinase 5, cdk5, and a 25 kDa subunit derived from a novel, neuron-specific, 35 kDa protein: p35. The characterization and regulation of nclk will be summarized in this minireview. The activity of nclk appears to be governed by highly complex regulatory mechanisms including protein-protien interaction, protein phosphorylation and isoforms. The histone H1 kinase activity of nclk is absolutely dependent of the interaction between the 25 kDa subunit and the catalytic subunit, cdk5. In addition, nclk interacts with other cellular proteins to form macromolecular complexes. The kinase activity of nclk is inhibited in vitro by the phosphorylation reactions of a weel-like protein tyrosine kinase and a protein serine/threonine kinase from bovine thymus. Northern blot analysis has revealed the existence of two populations of p35 mRNA of 2 and 4 kb. A novel cDNA encoding a p35 homologous protein has been obtained from a human hippocampus library.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalMolecular and Cellular Biochemistry
Volume149-150
Issue number1
DOIs
StatePublished - Aug 1 1995

Keywords

  • Alzheimer disease
  • cdk5
  • neurofilament proteins
  • neuronal cdc2-like kinase
  • regulatory subunit
  • tau

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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