Regulatory T cell-mediated transplantation tolerance

Ankit Bharat; Ryan Courtney Fields; T. Mohanakumar

doi:10.1385/IR:33:3:195

Regulatory T cell-mediated transplantation tolerance

Ankit Bharat, Ryan Courtney Fields, T. Mohanakumar^*

^*Corresponding author for this work

Surgery, Thoracic Surgery Division

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4⁺CD25⁺ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

Original language	English (US)
Pages (from-to)	195-212
Number of pages	18
Journal	Immunologic Research
Volume	33
Issue number	3
DOIs	https://doi.org/10.1385/IR:33:3:195
State	Published - Dec 2005

Funding

This work was supported by NIH HL56543 and HL66452 (T.M.). R.C.F. is a recipient of an ISHLT Research Fellowship Award and an AST Fellowship.

Keywords

Adaptive immune response
Antigen presentation
Infectious tolerance
Lung transplantation
Regulatory cells
T cells
Transplantation tolerance

ASJC Scopus subject areas

Immunology

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title = "Regulatory T cell-mediated transplantation tolerance",

abstract = "The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.",

keywords = "Adaptive immune response, Antigen presentation, Infectious tolerance, Lung transplantation, Regulatory cells, T cells, Transplantation tolerance",

author = "Ankit Bharat and Fields, {Ryan Courtney} and T. Mohanakumar",

note = "Funding Information: This work was supported by NIH HL56543 and HL66452 (T.M.). R.C.F. is a recipient of an ISHLT Research Fellowship Award and an AST Fellowship.",

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T1 - Regulatory T cell-mediated transplantation tolerance

AU - Bharat, Ankit

AU - Fields, Ryan Courtney

AU - Mohanakumar, T.

N1 - Funding Information: This work was supported by NIH HL56543 and HL66452 (T.M.). R.C.F. is a recipient of an ISHLT Research Fellowship Award and an AST Fellowship.

PY - 2005/12

Y1 - 2005/12

N2 - The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

AB - The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

KW - Adaptive immune response

KW - Antigen presentation

KW - Infectious tolerance

KW - Lung transplantation

KW - Regulatory cells

KW - T cells

KW - Transplantation tolerance

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DO - 10.1385/IR:33:3:195

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Regulatory T cell-mediated transplantation tolerance

Abstract

Funding

Keywords

ASJC Scopus subject areas

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