Regulatory T cell-mediated transplantation tolerance

Ankit Bharat, Ryan Courtney Fields, T. Mohanakumar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

Original languageEnglish (US)
Pages (from-to)195-212
Number of pages18
JournalImmunologic Research
Volume33
Issue number3
DOIs
StatePublished - Dec 2005

Keywords

  • Adaptive immune response
  • Antigen presentation
  • Infectious tolerance
  • Lung transplantation
  • Regulatory cells
  • T cells
  • Transplantation tolerance

ASJC Scopus subject areas

  • Immunology

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