Regulatory T cells actively infiltrate metastatic brain tumors

Adam Quasar Sugihara, Cleo E. Rolle, Maciej S. Lesniak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Regulatory T cells (CD46+CD25+FoxP3+, Treg) have been shown to play a major role in suppression of the immune response to malignant gliomas. In this study, we investigated the kinetics of Treg infiltration in metastatic brain tumor models, including melanoma, breast and colon cancers. Our data indicate that both CD4+ and Treg infiltration are significantly increased throughout the time of metastatic tumor progression. These findings were recapitulated in human CNS tumor samples of metastatic melanoma and nonsmall cell lung carcinoma. Collectively, these data support investigating immunotherapeutic strategies targeting Treg in metastatic CNS tumors.

Original languageEnglish (US)
Pages (from-to)1533-1540
Number of pages8
JournalInternational journal of oncology
Volume34
Issue number6
DOIs
StatePublished - 2009

Keywords

  • Brain tumors
  • Breast cancer
  • Colon cancer
  • Lung cancer
  • Melanoma
  • Metastases
  • Regulatory T cell (CD4CD25FoxP3, Treg)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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