Reimmunization after blood or marrow stem cell transplantation

S. Singhal*, J. Mehta

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Protective immunity to diseases preventable by routine vaccination is lost over time following allogeneic and autologous blood and marrow transplantation. Adoptive transfer of immunity from donors to recipients after allogeneic transplantation is not sufficient to prevent this decline. Systematic reimmunization is necessary at appropriate time intervals following transplantation to re-establish immunity. Response to vaccination depends upon the type of transplant, the source of cells, the immune status of the patient, and the vaccine being used. While inactivated or subunit vaccines are safe in all transplant recipients, live vaccines are generally contraindicated. Reimmunization practices vary widely amongst transplant centers. This comprehensive review summarizes published data on post-transplant vaccination, and based upon these, suggests guidelines which may be used as a framework for development of reimmunization protocols.

Original languageEnglish (US)
Pages (from-to)637-646
Number of pages10
JournalBone Marrow Transplantation
Volume23
Issue number7
DOIs
StatePublished - 1999

Keywords

  • Allogeneic bone marrow transplantation
  • Autologous bone marrow transplantation
  • Hematopoietic stem cell transplantation
  • Immunization
  • Vaccination

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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