Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex

H. T. Ghashghaei, Jill M. Weimer, Ralf S. Schmid, Yukako Yokota, Ken D. McCarthy, Brian Popko, E. S. Anton*

*Corresponding author for this work

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Radial glial cells play a critical role in the construction of mammalian brain by functioning as a source of new neurons and by providing a scaffold for radial migration of new neurons to their target locations. Radial glia transform into astrocytes at the end of embryonic development. Strategies to promote functional recovery in the injured adult brain depend on the generation of new neurons and the appropriate guidance of these neurons to where they are needed, two critical functions of radial glia. Thus, the competence to regain radial glial identity in the adult brain is of significance for the ability to promote functional repair via neurogenesis and targeted neuronal migration in the mature brain. Here we show that the in vivo induction of the tyrosine kinase receptor, ErbB2, in mature astrocytes enables a subset of them to regain radial glial identity in the mature cerebral cortex. These new radial glial progenitors are capable of giving rise to new neurons and can support neuronal migration. These studies indicate that ErbB2 signaling critically modulates the functional state of radial glia, and induction of ErbB2 in distinct adult astrocytes can promote radial glial identity in the mature cerebral cortex.

Original languageEnglish (US)
Pages (from-to)3258-3271
Number of pages14
JournalGenes and Development
Volume21
Issue number24
DOIs
StatePublished - Dec 15 2007

Keywords

  • Cortical development
  • ErbB receptors
  • Neuregulins
  • Neurogenesis
  • Radial glia

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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    Ghashghaei, H. T., Weimer, J. M., Schmid, R. S., Yokota, Y., McCarthy, K. D., Popko, B., & Anton, E. S. (2007). Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes and Development, 21(24), 3258-3271. https://doi.org/10.1101/gad.1580407