Rejection of murine melanoma cells transfected with the intercellular adhesion molecule-1 gene

P. W. Chen; V. K. Shreedhar; H. N. Ananthaswamy

doi:10.3892/ijo.6.3.675

Rejection of murine melanoma cells transfected with the intercellular adhesion molecule-1 gene

P. W. Chen, V. K. Shreedhar, H. N. Ananthaswamy^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The effects of intercellular adhesion molecule-1 (ICAM-1) expression on tumor rejection and induction of antitumor immunity in a murine melanomasystem was studied. K1735 melanoma cells genetically engineered to express the murine ICAM-1 gene were rejected in immunocompetent hosts, and that this rejection was mediated by CD4⁺ as well as by CD8⁺ T lymphocytes. We also found that ICAM-1 transfected tumor cells provided costimulatory signals to both CD4⁺ and CD8⁺ T cells in vitro. In addition, immunization of mice with K1735-ICAM-1 transfectants induced protective immunity against the parental ICAM-1-negative tumor. Our findings suggest that ICAM-1 expression on nonimmunogenic tumor cells causes tumor rejection and augments tumor-specific immunity.

Original language	English (US)
Pages (from-to)	675-680
Number of pages	6
Journal	International journal of oncology
Volume	6
Issue number	3
DOIs	https://doi.org/10.3892/ijo.6.3.675
State	Published - 1995
Externally published	Yes

Keywords

ICAM-1
cell adhesion
costimulation
melanoma
tumor immunity

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/ijo.6.3.675

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title = "Rejection of murine melanoma cells transfected with the intercellular adhesion molecule-1 gene",

abstract = "The effects of intercellular adhesion molecule-1 (ICAM-1) expression on tumor rejection and induction of antitumor immunity in a murine melanomasystem was studied. K1735 melanoma cells genetically engineered to express the murine ICAM-1 gene were rejected in immunocompetent hosts, and that this rejection was mediated by CD4+ as well as by CD8+ T lymphocytes. We also found that ICAM-1 transfected tumor cells provided costimulatory signals to both CD4+ and CD8+ T cells in vitro. In addition, immunization of mice with K1735-ICAM-1 transfectants induced protective immunity against the parental ICAM-1-negative tumor. Our findings suggest that ICAM-1 expression on nonimmunogenic tumor cells causes tumor rejection and augments tumor-specific immunity.",

keywords = "ICAM-1, cell adhesion, costimulation, melanoma, tumor immunity",

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T1 - Rejection of murine melanoma cells transfected with the intercellular adhesion molecule-1 gene

AU - Chen, P. W.

AU - Shreedhar, V. K.

AU - Ananthaswamy, H. N.

PY - 1995

Y1 - 1995

N2 - The effects of intercellular adhesion molecule-1 (ICAM-1) expression on tumor rejection and induction of antitumor immunity in a murine melanomasystem was studied. K1735 melanoma cells genetically engineered to express the murine ICAM-1 gene were rejected in immunocompetent hosts, and that this rejection was mediated by CD4+ as well as by CD8+ T lymphocytes. We also found that ICAM-1 transfected tumor cells provided costimulatory signals to both CD4+ and CD8+ T cells in vitro. In addition, immunization of mice with K1735-ICAM-1 transfectants induced protective immunity against the parental ICAM-1-negative tumor. Our findings suggest that ICAM-1 expression on nonimmunogenic tumor cells causes tumor rejection and augments tumor-specific immunity.

AB - The effects of intercellular adhesion molecule-1 (ICAM-1) expression on tumor rejection and induction of antitumor immunity in a murine melanomasystem was studied. K1735 melanoma cells genetically engineered to express the murine ICAM-1 gene were rejected in immunocompetent hosts, and that this rejection was mediated by CD4+ as well as by CD8+ T lymphocytes. We also found that ICAM-1 transfected tumor cells provided costimulatory signals to both CD4+ and CD8+ T cells in vitro. In addition, immunization of mice with K1735-ICAM-1 transfectants induced protective immunity against the parental ICAM-1-negative tumor. Our findings suggest that ICAM-1 expression on nonimmunogenic tumor cells causes tumor rejection and augments tumor-specific immunity.

KW - ICAM-1

KW - cell adhesion

KW - costimulation

KW - melanoma

KW - tumor immunity

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Rejection of murine melanoma cells transfected with the intercellular adhesion molecule-1 gene

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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