Rejection of murine melanoma cells transfected with the intercellular adhesion molecule-1 gene

P. W. Chen, V. K. Shreedhar, H. N. Ananthaswamy*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The effects of intercellular adhesion molecule-1 (ICAM-1) expression on tumor rejection and induction of antitumor immunity in a murine melanomasystem was studied. K1735 melanoma cells genetically engineered to express the murine ICAM-1 gene were rejected in immunocompetent hosts, and that this rejection was mediated by CD4+ as well as by CD8+ T lymphocytes. We also found that ICAM-1 transfected tumor cells provided costimulatory signals to both CD4+ and CD8+ T cells in vitro. In addition, immunization of mice with K1735-ICAM-1 transfectants induced protective immunity against the parental ICAM-1-negative tumor. Our findings suggest that ICAM-1 expression on nonimmunogenic tumor cells causes tumor rejection and augments tumor-specific immunity.

Original languageEnglish (US)
Pages (from-to)675-680
Number of pages6
JournalInternational journal of oncology
Volume6
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • cell adhesion
  • costimulation
  • ICAM-1
  • melanoma
  • tumor immunity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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