Relation between blood pressure and pulse wave velocity for human arteries

Yinji Ma, Jungil Choi, Aurélie Hourlier-Fargette, Yeguang Xue, Ha Uk Chung, Jong Yoon Lee, Xiufeng Wang, Zhaoqian Xie, Daeshik Kang, Heling Wang, Seungyong Han, Seung Kyun Kang, Yisak Kang, Xinge Yu, Marvin J. Slepian, Milan S. Raj, Jeffrey B. Model, Xue Feng, Roozbeh Ghaffari, John A Rogers & 1 others Yonggang Huang*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Continuous monitoring of blood pressure, an essential measure of health status, typically requires complex, costly, and invasive techniques that can expose patients to risks of complications. Continuous, cuffless, and noninvasive blood pressure monitoring methods that correlate measured pulse wave velocity (PWV) to the blood pressure via the Moens-Korteweg (MK) and Hughes Equations, offer promising alternatives. The MK Equation, however, involves two assumptions that do not hold for human arteries, and the Hughes Equation is empirical, without any theoretical basis. The results presented here establish a relation between the blood pressure P and PWV that does not rely on the Hughes Equation nor on the assumptions used in the MK Equation. This relation degenerates to the MK Equation under extremely low blood pressures, and it accurately captures the results of in vitro experiments using artificial blood vessels at comparatively high pressures. For human arteries, which are well characterized by the Fung hyperelastic model, a simple formula between P and PWV is established within the range of human blood pressures. This formula is validated by literature data as well as by experiments on human subjects, with applicability in the determination of blood pressure from PWV in continuous, cuffless, and noninvasive blood pressure monitoring systems.

Original languageEnglish (US)
Pages (from-to)11144-11149
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number44
DOIs
StatePublished - Oct 30 2018

Fingerprint

Pulse Wave Analysis
Arteries
Blood Pressure
Blood Pressure Determination
Blood Substitutes
Hypotension
Health Status
Blood Vessels
Pressure

Keywords

  • Arterial stiffness
  • Artery hyperelastic model
  • Blood pressure
  • Hemodynamics
  • Pulse wave velocity

ASJC Scopus subject areas

  • General

Cite this

Ma, Yinji ; Choi, Jungil ; Hourlier-Fargette, Aurélie ; Xue, Yeguang ; Chung, Ha Uk ; Lee, Jong Yoon ; Wang, Xiufeng ; Xie, Zhaoqian ; Kang, Daeshik ; Wang, Heling ; Han, Seungyong ; Kang, Seung Kyun ; Kang, Yisak ; Yu, Xinge ; Slepian, Marvin J. ; Raj, Milan S. ; Model, Jeffrey B. ; Feng, Xue ; Ghaffari, Roozbeh ; Rogers, John A ; Huang, Yonggang. / Relation between blood pressure and pulse wave velocity for human arteries. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 44. pp. 11144-11149.
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abstract = "Continuous monitoring of blood pressure, an essential measure of health status, typically requires complex, costly, and invasive techniques that can expose patients to risks of complications. Continuous, cuffless, and noninvasive blood pressure monitoring methods that correlate measured pulse wave velocity (PWV) to the blood pressure via the Moens-Korteweg (MK) and Hughes Equations, offer promising alternatives. The MK Equation, however, involves two assumptions that do not hold for human arteries, and the Hughes Equation is empirical, without any theoretical basis. The results presented here establish a relation between the blood pressure P and PWV that does not rely on the Hughes Equation nor on the assumptions used in the MK Equation. This relation degenerates to the MK Equation under extremely low blood pressures, and it accurately captures the results of in vitro experiments using artificial blood vessels at comparatively high pressures. For human arteries, which are well characterized by the Fung hyperelastic model, a simple formula between P and PWV is established within the range of human blood pressures. This formula is validated by literature data as well as by experiments on human subjects, with applicability in the determination of blood pressure from PWV in continuous, cuffless, and noninvasive blood pressure monitoring systems.",
keywords = "Arterial stiffness, Artery hyperelastic model, Blood pressure, Hemodynamics, Pulse wave velocity",
author = "Yinji Ma and Jungil Choi and Aur{\'e}lie Hourlier-Fargette and Yeguang Xue and Chung, {Ha Uk} and Lee, {Jong Yoon} and Xiufeng Wang and Zhaoqian Xie and Daeshik Kang and Heling Wang and Seungyong Han and Kang, {Seung Kyun} and Yisak Kang and Xinge Yu and Slepian, {Marvin J.} and Raj, {Milan S.} and Model, {Jeffrey B.} and Xue Feng and Roozbeh Ghaffari and Rogers, {John A} and Yonggang Huang",
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Ma, Y, Choi, J, Hourlier-Fargette, A, Xue, Y, Chung, HU, Lee, JY, Wang, X, Xie, Z, Kang, D, Wang, H, Han, S, Kang, SK, Kang, Y, Yu, X, Slepian, MJ, Raj, MS, Model, JB, Feng, X, Ghaffari, R, Rogers, JA & Huang, Y 2018, 'Relation between blood pressure and pulse wave velocity for human arteries', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 44, pp. 11144-11149. https://doi.org/10.1073/pnas.1814392115

Relation between blood pressure and pulse wave velocity for human arteries. / Ma, Yinji; Choi, Jungil; Hourlier-Fargette, Aurélie; Xue, Yeguang; Chung, Ha Uk; Lee, Jong Yoon; Wang, Xiufeng; Xie, Zhaoqian; Kang, Daeshik; Wang, Heling; Han, Seungyong; Kang, Seung Kyun; Kang, Yisak; Yu, Xinge; Slepian, Marvin J.; Raj, Milan S.; Model, Jeffrey B.; Feng, Xue; Ghaffari, Roozbeh; Rogers, John A; Huang, Yonggang.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 44, 30.10.2018, p. 11144-11149.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relation between blood pressure and pulse wave velocity for human arteries

AU - Ma, Yinji

AU - Choi, Jungil

AU - Hourlier-Fargette, Aurélie

AU - Xue, Yeguang

AU - Chung, Ha Uk

AU - Lee, Jong Yoon

AU - Wang, Xiufeng

AU - Xie, Zhaoqian

AU - Kang, Daeshik

AU - Wang, Heling

AU - Han, Seungyong

AU - Kang, Seung Kyun

AU - Kang, Yisak

AU - Yu, Xinge

AU - Slepian, Marvin J.

AU - Raj, Milan S.

AU - Model, Jeffrey B.

AU - Feng, Xue

AU - Ghaffari, Roozbeh

AU - Rogers, John A

AU - Huang, Yonggang

PY - 2018/10/30

Y1 - 2018/10/30

N2 - Continuous monitoring of blood pressure, an essential measure of health status, typically requires complex, costly, and invasive techniques that can expose patients to risks of complications. Continuous, cuffless, and noninvasive blood pressure monitoring methods that correlate measured pulse wave velocity (PWV) to the blood pressure via the Moens-Korteweg (MK) and Hughes Equations, offer promising alternatives. The MK Equation, however, involves two assumptions that do not hold for human arteries, and the Hughes Equation is empirical, without any theoretical basis. The results presented here establish a relation between the blood pressure P and PWV that does not rely on the Hughes Equation nor on the assumptions used in the MK Equation. This relation degenerates to the MK Equation under extremely low blood pressures, and it accurately captures the results of in vitro experiments using artificial blood vessels at comparatively high pressures. For human arteries, which are well characterized by the Fung hyperelastic model, a simple formula between P and PWV is established within the range of human blood pressures. This formula is validated by literature data as well as by experiments on human subjects, with applicability in the determination of blood pressure from PWV in continuous, cuffless, and noninvasive blood pressure monitoring systems.

AB - Continuous monitoring of blood pressure, an essential measure of health status, typically requires complex, costly, and invasive techniques that can expose patients to risks of complications. Continuous, cuffless, and noninvasive blood pressure monitoring methods that correlate measured pulse wave velocity (PWV) to the blood pressure via the Moens-Korteweg (MK) and Hughes Equations, offer promising alternatives. The MK Equation, however, involves two assumptions that do not hold for human arteries, and the Hughes Equation is empirical, without any theoretical basis. The results presented here establish a relation between the blood pressure P and PWV that does not rely on the Hughes Equation nor on the assumptions used in the MK Equation. This relation degenerates to the MK Equation under extremely low blood pressures, and it accurately captures the results of in vitro experiments using artificial blood vessels at comparatively high pressures. For human arteries, which are well characterized by the Fung hyperelastic model, a simple formula between P and PWV is established within the range of human blood pressures. This formula is validated by literature data as well as by experiments on human subjects, with applicability in the determination of blood pressure from PWV in continuous, cuffless, and noninvasive blood pressure monitoring systems.

KW - Arterial stiffness

KW - Artery hyperelastic model

KW - Blood pressure

KW - Hemodynamics

KW - Pulse wave velocity

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