Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: Systematic review and meta-analysis

Hsu Ko Kuo, Chung Jen Yen, Chia Hsuin Chang, Chen Ko Kuo, Jen Hau Chen, Farzaneh Sorond

Research output: Contribution to journalReview article

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Abstract

Evidence suggests that a high concentration of C-reactive protein (CRP) is a cardiovascular risk factor and an important correlate of cognitive disorders and depression. Recently, population-based studies examining the association between CRP and stroke, cognitive impairment, or depression have been done but have not yet been systematically reviewed. Here we present a systematic review of the associations between CRP and stroke, cognitive impairment, and depression. Hospital or clinic-based studies were excluded because the inferences might not be easily applicable to the general population. 19 eligible studies of CRP were selected: seven for stroke, six for cognitive disorders, and six for depression. Raised CRP concentrations were associated with history of stroke and increased risk of incident stroke. Meta-analysis of studies with long follow-up (>8 years) showed that the risk for stroke in healthy individuals with the highest quartile of CRP concentrations increased nearly 70% compared to those with the lowest quartile. High concentrations of CRP were predictive of cognitive decline and dementia. The relations of CRP to depression were all cross-sectional and were not consistent. We conclude that high concentrations of CRP are associated with increased risk of stroke and cognitive impairment. The association between CRP and depression should be studied prospectively.

LanguageEnglish (US)
Pages371-380
Number of pages10
JournalLancet Neurology
Volume4
Issue number6
DOIs
StatePublished - Jun 1 2005

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C-Reactive Protein
Meta-Analysis
Stroke
Depression
Population
Adjustment Disorders
Dementia
Cognitive Dysfunction

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Kuo, Hsu Ko ; Yen, Chung Jen ; Chang, Chia Hsuin ; Kuo, Chen Ko ; Chen, Jen Hau ; Sorond, Farzaneh. / Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population : Systematic review and meta-analysis. In: Lancet Neurology. 2005 ; Vol. 4, No. 6. pp. 371-380
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Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population : Systematic review and meta-analysis. / Kuo, Hsu Ko; Yen, Chung Jen; Chang, Chia Hsuin; Kuo, Chen Ko; Chen, Jen Hau; Sorond, Farzaneh.

In: Lancet Neurology, Vol. 4, No. 6, 01.06.2005, p. 371-380.

Research output: Contribution to journalReview article

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