Relation of dietary sodium (Salt) to blood pressure and its possible modulation by other dietary factors the intermap study

Jeremiah Stamler*, Queenie Chan, Martha L. Daviglus, Alan R. Dyer, Linda Van Horn, Daniel B. Garside, Katsuyuki Miura, Yangfeng Wu, Hirotsugu Ueshima, Liancheng Zhao, Paul Elliott

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Available data indicate that dietary sodium (as salt) relates directly to blood pressure (BP). Most of these findings are from studies lacking dietary data; hence, it is unclear whether this sodium-BP relationship is modulated by other dietary factors. With control for multiple nondietary factors, but not body mass index, there were direct relations to BP of 24-hour urinary sodium excretion and the urinary sodium/potassium ratio among 4680 men and women 40 to 59 years of age (17 population samples in China, Japan, United Kingdom, and United States) in the INTERMAP (International Study on Macro/Micronutrients and Blood Pressure), and among its 2195 American participants, for example, 2 SD higher 24-hour urinary sodium excretion (118.7 mmol) associated with systolic BP 3.7 mm Hg higher. These sodium-BP relations persisted with control for 13 macronutrients, 12 vitamins, 7 minerals, and 18 amino acids, for both sex, older and younger, blacks, Hispanics, whites, and socioeconomic strata. With control for body mass index, sodium-BP-but not sodium/potassium-BP-relations were attenuated. Normal weight and obese participants manifested significant positive relations to BP of urinary sodium; relations were weaker for overweight people. At lower but not higher levels of 24-hour sodium excretion, potassium intake blunted the sodium-BP relation. The adverse association of dietary sodium with BP is minimally attenuated by other dietary constituents; these findings underscore the importance of reducing salt intake for the prevention and control of prehypertension and hypertension.

Original languageEnglish (US)
Pages (from-to)631-637
Number of pages7
Issue number4
StatePublished - 2018


  • Blood pressure
  • Diet
  • Hypertension
  • Potassium
  • Sodium

ASJC Scopus subject areas

  • Internal Medicine


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