Relation of Left Ventricular Assist Device Infections With Cardiac Transplant Outcomes

Aditya Parikh*, Michael Halista, Samantha Raymond, Jason Feinman, Donna Mancini, Sumeet Mitter, Maya Barghash, Maria Trivieri, Johanna Contreras, Sarah Taimur, Julie Roldan, Joseph Murphy, Amit Pawale, Anelechi Anyanwu, Noah Moss, Anuradha Lala, Sean Pinney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Left ventricular assist device (LVAD)–specific infections (LSIs) are common in patients on LVAD support awaiting heart transplant (HT), yet their impact on post-HT outcomes is not completely understood. We hypothesized that LSIs would result in vasoplegia and negatively affect post-HT 30-day and 1-year outcomes. LSI was defined as driveline, pump, or pocket infection. The short-term outcome was a composite of acute renal failure, allograft rejection, and mortality at 30 days after HT. The long-term outcome was a composite of allograft rejection and death within 1 year after HT. We performed a retrospective analysis of 111 HT recipients bridged with durable LVAD support at our institution from May 2012 to August 2019. Of these, 63 patients had LSIs, with 94% of the infections being driveline infections. Vasoplegia was more prevalent in the LSI group but not significantly (7 vs 2 persons, p = 0.3). There was no difference in the composite end point of acute renal failure, rejection, or death at 30 days (30% vs 25%, p = 0.55) or 1-year end point of rejection and death (38% vs 40%, p = 0.87) in patients with LSI versus those without LSI. In conclusion, LSIs were common in patients on LVAD who underwent HT in our single-center contemporary cohort. However, LSI was not associated with adverse outcomes at 30 days or at 1 year after HT.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalAmerican Journal of Cardiology
Volume160
DOIs
StatePublished - Dec 1 2021
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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