Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study

Nagako Okuda; Hirotsugu Ueshima; Akira Okayama; Shigeyuki Saitoh; Hideaki Nakagawa; Beatriz L. Rodriguez; Kiyomi Sakata; Sohel R. Choudhury; J. David Curb; Jeremiah Stamler

doi:10.1016/j.atherosclerosis.2004.09.007

Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study

Nagako Okuda^*, Hirotsugu Ueshima, Akira Okayama, Shigeyuki Saitoh, Hideaki Nakagawa, Beatriz L. Rodriguez, Kiyomi Sakata, Sohel R. Choudhury, J. David Curb, Jeremiah Stamler

^*Corresponding author for this work

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Abstract

Epidemiologic evidence shows an inverse relationship between fish consumption and coronary heart disease (CHD) mortality. Associations between dietary intake of long chain n-3 polyunsaturated fatty acids (PUFA) and serum high density lipoprotein (HDL) cholesterol concentration are unknown. In this study, the association between n-3 PUFA (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA)) intake and serum HDL cholesterol among Japanese men and women in Japan and Hawaii was examined. The study population consisted of Japanese ancestries from five research centers of the International Study of Macronutrients and Blood Pressure (INTERMAP) study, in Japan and Hawaii (672 men and 676 women), surveyed between 1996 and 1998. Four 24-h dietary recalls and one set of serum lipid measurements were performed. For men, n-3 PUFA intake and HDL cholesterol were higher in Japan than in Hawaii (n-3 PUFA: 1.32 g/day versus 0.47 g/day, p < 0.001). For women, n-3 PUFA intake was higher in Japan than in Hawaii (p < 0.001) but HDL cholesterol was not significantly different (p = 0.752). After adjustment for age, body mass index, physical activity, number of cigarettes per day, alcohol intake, and hormone replacement therapy (for women), n-3 PUFA intake was positively associated with serum HDL cholesterol in men (4.6 mg/dl higher HDL cholesterol with 1%kcal higher n-3 PUFA intake, p = 0.011). This association was not observed in women. This positive association of dietary n-3 PUFA with serum HDL cholesterol may partially explain the low mortality from CHD among Japanese men.

Original language	English (US)
Pages (from-to)	371-379
Number of pages	9
Journal	Atherosclerosis
Volume	178
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2004.09.007
State	Published - Feb 2005

Funding

This study was partly supported by the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (A), no. 090357003 in Japan and the Suntory Company; the Pacific Research Institute is supported by the Robert Perry Fund and the Hawaii Community Foundation. The INTERMAP Hawaii Center was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant 5-RO1-HL54868-03). The INTERMAP study is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A. (Grant 2-RO1-HL50490-06), as well as national and local agencies in the four countries.

Keywords

Coronary disease
Diet
Fish oils
HDL cholesterol
Japan
Omega-3 fatty acids
Population study

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2004.09.007

Cite this

Okuda, N., Ueshima, H., Okayama, A., Saitoh, S., Nakagawa, H., Rodriguez, B. L., Sakata, K., Choudhury, S. R., Curb, J. D., & Stamler, J. (2005). Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study. Atherosclerosis, 178(2), 371-379. https://doi.org/10.1016/j.atherosclerosis.2004.09.007

@article{462d67b38d6a45069eea479db759d350,

title = "Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study",

abstract = "Epidemiologic evidence shows an inverse relationship between fish consumption and coronary heart disease (CHD) mortality. Associations between dietary intake of long chain n-3 polyunsaturated fatty acids (PUFA) and serum high density lipoprotein (HDL) cholesterol concentration are unknown. In this study, the association between n-3 PUFA (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA)) intake and serum HDL cholesterol among Japanese men and women in Japan and Hawaii was examined. The study population consisted of Japanese ancestries from five research centers of the International Study of Macronutrients and Blood Pressure (INTERMAP) study, in Japan and Hawaii (672 men and 676 women), surveyed between 1996 and 1998. Four 24-h dietary recalls and one set of serum lipid measurements were performed. For men, n-3 PUFA intake and HDL cholesterol were higher in Japan than in Hawaii (n-3 PUFA: 1.32 g/day versus 0.47 g/day, p < 0.001). For women, n-3 PUFA intake was higher in Japan than in Hawaii (p < 0.001) but HDL cholesterol was not significantly different (p = 0.752). After adjustment for age, body mass index, physical activity, number of cigarettes per day, alcohol intake, and hormone replacement therapy (for women), n-3 PUFA intake was positively associated with serum HDL cholesterol in men (4.6 mg/dl higher HDL cholesterol with 1%kcal higher n-3 PUFA intake, p = 0.011). This association was not observed in women. This positive association of dietary n-3 PUFA with serum HDL cholesterol may partially explain the low mortality from CHD among Japanese men.",

keywords = "Coronary disease, Diet, Fish oils, HDL cholesterol, Japan, Omega-3 fatty acids, Population study",

author = "Nagako Okuda and Hirotsugu Ueshima and Akira Okayama and Shigeyuki Saitoh and Hideaki Nakagawa and Rodriguez, {Beatriz L.} and Kiyomi Sakata and Choudhury, {Sohel R.} and Curb, {J. David} and Jeremiah Stamler",

note = "Funding Information: This study was partly supported by the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (A), no. 090357003 in Japan and the Suntory Company; the Pacific Research Institute is supported by the Robert Perry Fund and the Hawaii Community Foundation. The INTERMAP Hawaii Center was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant 5-RO1-HL54868-03). The INTERMAP study is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A. (Grant 2-RO1-HL50490-06), as well as national and local agencies in the four countries.",

year = "2005",

month = feb,

doi = "10.1016/j.atherosclerosis.2004.09.007",

language = "English (US)",

volume = "178",

pages = "371--379",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

Okuda, N, Ueshima, H, Okayama, A, Saitoh, S, Nakagawa, H, Rodriguez, BL, Sakata, K, Choudhury, SR, Curb, JD & Stamler, J 2005, 'Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study', Atherosclerosis, vol. 178, no. 2, pp. 371-379. https://doi.org/10.1016/j.atherosclerosis.2004.09.007

Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study. / Okuda, Nagako; Ueshima, Hirotsugu; Okayama, Akira et al.
In: Atherosclerosis, Vol. 178, No. 2, 02.2005, p. 371-379.

Research output: Contribution to journal › Article › peer-review

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T1 - Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii

T2 - The INTERLIPID study

AU - Okuda, Nagako

AU - Ueshima, Hirotsugu

AU - Okayama, Akira

AU - Saitoh, Shigeyuki

AU - Nakagawa, Hideaki

AU - Rodriguez, Beatriz L.

AU - Sakata, Kiyomi

AU - Choudhury, Sohel R.

AU - Curb, J. David

AU - Stamler, Jeremiah

N1 - Funding Information: This study was partly supported by the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (A), no. 090357003 in Japan and the Suntory Company; the Pacific Research Institute is supported by the Robert Perry Fund and the Hawaii Community Foundation. The INTERMAP Hawaii Center was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant 5-RO1-HL54868-03). The INTERMAP study is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A. (Grant 2-RO1-HL50490-06), as well as national and local agencies in the four countries.

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N2 - Epidemiologic evidence shows an inverse relationship between fish consumption and coronary heart disease (CHD) mortality. Associations between dietary intake of long chain n-3 polyunsaturated fatty acids (PUFA) and serum high density lipoprotein (HDL) cholesterol concentration are unknown. In this study, the association between n-3 PUFA (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA)) intake and serum HDL cholesterol among Japanese men and women in Japan and Hawaii was examined. The study population consisted of Japanese ancestries from five research centers of the International Study of Macronutrients and Blood Pressure (INTERMAP) study, in Japan and Hawaii (672 men and 676 women), surveyed between 1996 and 1998. Four 24-h dietary recalls and one set of serum lipid measurements were performed. For men, n-3 PUFA intake and HDL cholesterol were higher in Japan than in Hawaii (n-3 PUFA: 1.32 g/day versus 0.47 g/day, p < 0.001). For women, n-3 PUFA intake was higher in Japan than in Hawaii (p < 0.001) but HDL cholesterol was not significantly different (p = 0.752). After adjustment for age, body mass index, physical activity, number of cigarettes per day, alcohol intake, and hormone replacement therapy (for women), n-3 PUFA intake was positively associated with serum HDL cholesterol in men (4.6 mg/dl higher HDL cholesterol with 1%kcal higher n-3 PUFA intake, p = 0.011). This association was not observed in women. This positive association of dietary n-3 PUFA with serum HDL cholesterol may partially explain the low mortality from CHD among Japanese men.

AB - Epidemiologic evidence shows an inverse relationship between fish consumption and coronary heart disease (CHD) mortality. Associations between dietary intake of long chain n-3 polyunsaturated fatty acids (PUFA) and serum high density lipoprotein (HDL) cholesterol concentration are unknown. In this study, the association between n-3 PUFA (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA)) intake and serum HDL cholesterol among Japanese men and women in Japan and Hawaii was examined. The study population consisted of Japanese ancestries from five research centers of the International Study of Macronutrients and Blood Pressure (INTERMAP) study, in Japan and Hawaii (672 men and 676 women), surveyed between 1996 and 1998. Four 24-h dietary recalls and one set of serum lipid measurements were performed. For men, n-3 PUFA intake and HDL cholesterol were higher in Japan than in Hawaii (n-3 PUFA: 1.32 g/day versus 0.47 g/day, p < 0.001). For women, n-3 PUFA intake was higher in Japan than in Hawaii (p < 0.001) but HDL cholesterol was not significantly different (p = 0.752). After adjustment for age, body mass index, physical activity, number of cigarettes per day, alcohol intake, and hormone replacement therapy (for women), n-3 PUFA intake was positively associated with serum HDL cholesterol in men (4.6 mg/dl higher HDL cholesterol with 1%kcal higher n-3 PUFA intake, p = 0.011). This association was not observed in women. This positive association of dietary n-3 PUFA with serum HDL cholesterol may partially explain the low mortality from CHD among Japanese men.

KW - Coronary disease

KW - Diet

KW - Fish oils

KW - HDL cholesterol

KW - Japan

KW - Omega-3 fatty acids

KW - Population study

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AN - SCOPUS:19944432640

SN - 0021-9150

VL - 178

SP - 371

EP - 379

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: The INTERLIPID study

Abstract

Funding

Keywords

ASJC Scopus subject areas

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