Relation of Pregnancy Loss to Risk of Cardiovascular Disease in Parous Postmenopausal Women (From the Women's Health Initiative)

Philip S. Hall*, Gregory Nah, Eric Vittinghoff, Donna R. Parker, Jo Ann E. Manson, Barbara V. Howard, Gloria E. Sarto, Margery L. Gass, Shawnita M. Sealy-Jefferson, Elena Salmoirago-Blotcher, Marcia L. Stefanick, Aladdin H. Shadyab, Linda V. Van Horn, Ki Park, Nisha I. Parikh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Women with history of pregnancy loss (PL) have higher burden of cardiovascular disease (CVD) later in life, yet it is unclear whether this is attributable to an association with established CVD risk factors (RFs). We examined whether PL is associated with CVD RFs and biomarkers in parous postmenopausal women in the Women's Health Initiative, and whether the association between PL and CVD RFs accounted for the association between PL and incident CVD. Linear and logistic regressions were used to estimate associations between baseline history of PL and CVD RFs. Cox proportional hazards regression models were used to estimate the associations between baseline history of PL and incident CVD after adjustment for baseline RFs. Of 79,121 women, 27,272 (35%) had experienced PL. History of PL was associated with higher body mass index (p < 0.0001), hypertension (p < 0.0001), diabetes (p = 0.003), depression (p < 0.0001), and lower income (p < 0.0001), physical activity (p = 0.01), poorer diet (p < 0.0001), smoking (p < 0.0001), and alcohol use (p < 0.0001). After adjustment for CVD RFs, PL was significantly associated with incident CVD over mean follow up of 16 years (hazard ratio 1.11, 95% confidence interval 1.06 to 1.16). In conclusion, several CVD RFs are associated with PL, but they do not entirely account for the association between PL and incident CVD.

Original languageEnglish (US)
Pages (from-to)1620-1625
Number of pages6
JournalAmerican Journal of Cardiology
Volume123
Issue number10
DOIs
StatePublished - May 15 2019

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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