Relation of ventricular premature beats to underlying heart disease

Eugene F. Uretz*, Pablo Denes, Neal Ruggie, Emmanuel Vasilomanolakis, Joseph V. Messer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The relation between ventricular premature beats (VPBs) and physiologic disease was investigated in 305 patients who had 24-hour Holter monitoring tests, cardiac catheterization and angiography. Both frequency and Lown class of VPBs were measured. Analyses showed that occurrence of VPBs at an average frequency of more than 2 per hour or occurrence of complex VPBs (Lown class greater than 2) have the highest association with the presence and severity of cardiac disease. Using these criteria, VPB severity was then compared with extent of ventricular wall motion abnormality (right anterior oblique projection segments), ejection fraction, end-diastolic pressure, category of disease (normal, coronary artery disease [CAD], valvular heart disease, dilated cardiomyopathy), age and severity of CAD (major coronary arteries with >75 % diameter reduction). Severe VPBs defined either by complexity or frequency were significantly correlated with extent of wall motion abnormality, ejection fraction, category of disease and age. Severe VPBs were not significantly correlated with end-diastolic pressure or severity of CAD. Discriminant analysis then showed that in addition to wall motion abnormality and ejection fraction, category of disease and age are independently correlated with VPB severity.

Original languageEnglish (US)
Pages (from-to)774-780
Number of pages7
JournalThe American Journal of Cardiology
Issue number6
StatePublished - Mar 1 1984

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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