Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma

Prescott G. Woodruff, Ramin Khashayar, Stephen C. Lazarus, Susan Janson, Pedro Avila, Homer A. Boushey, Mark Segal, John V. Fahy*

*Corresponding author for this work

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

Background: Although the role of eosinophils in airway inflammation in chronic asthma has been extensively studied, a role for neutrophils has not been well characterized. Furthermore, prior studies have not systematically sought or controlled for factors that might confound the relationship between cellular markers of inflammation and physiologic measures of airway function. Objective: The purpose of this study was to determine whether eosinophilic and neutrophilic inflammation independently contribute to abnormalities of airway function in asthma. Methods: Multivariate analysis of data collected during screening and enrollment of 205 asthmatic adults for clinical trials was conducted to examine the relationships between cellular inflammation in induced sputum and FEV1 and methacholine responsiveness (PC20) while confounding factors were controlled for. Results: We found that age, sex, ethnicity, and use of inhaled corticosteroids were important confounding factors of the relationship between cellular inflammation and airway function. When these factors were controlled for, multivariate analysis showed that eosinophil percentage in induced sputum is independently associated with lower FEV1 and lower PC20 (P = .005 and P = .005, respectively). In the same models, increased sputum neutrophil percentage is independently associated with lower FEV1 (P = .038) but not with PC20 (P = .49). Conclusions: These results suggest that both eosinophilic inflammation and neutrophilic inflammation independently contribute to abnormalities of FEV1 in asthma. Therapies directed specifically at control of neutrophilic inflammation might be useful in improving airway caliber in patients with chronic asthma.

Original languageEnglish (US)
Article number119411
Pages (from-to)753-758
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume108
Issue number5
DOIs
StatePublished - 2001

Keywords

  • Airway obstruction
  • Asthma
  • Eosinophils
  • Neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Woodruff, P. G., Khashayar, R., Lazarus, S. C., Janson, S., Avila, P., Boushey, H. A., Segal, M., & Fahy, J. V. (2001). Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. Journal of Allergy and Clinical Immunology, 108(5), 753-758. [119411]. https://doi.org/10.1067/mai.2001.119411