Relationship Between Left Atrial and Left Ventricular Function in Hypertrophic Cardiomyopathy: A Real-time 3-Dimensional Echocardiographic Study

Mi Seung Shin, Shota Fukuda, Jong Min Song, Hung Tran, Stephanie Oryszak, James D. Thomas, Takahiro Shiota*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background: Left atrium (LA) in patients with hypertrophic cardiomyopathy (HC) has been known to have an increased size and decreased contractile function. The purpose of this study was to investigate LA and left ventricular (LV) volume change and function with real-time 3-dimensional (3D) echocardiography and to investigate association between LA and LV function in HC. Methods: We performed real-time 3D echocardiography on 26 patients with HC and on 15 control subjects. LA and LV time-volume curves were obtained from real-time 3D echocardiography and the maximal slope of the time-volume curve was expressed as dV/dt. LA active emptying fraction was calculated as: [(precontraction LA volume - minimal LA volume)/precontraction LA volume] × 100. Results: The maximal LA volume index was larger, and LA active emptying fraction was lower, in those with HC than control subjects (50.1 ± 15.9 vs 30.1 ± 6.8 mL/m2 and 33.3 ± 13.7 vs 40.4 ± 8.6%, both P < .05). LA active emptying fraction showed a negative correlation with precontraction LA volume (r = -0.64, P < .01) in HC. Patients with HC showed decreased LV early diastolic dV/dt compared with control subjects (0.10 ± 0.05 vs 0.14 ± 0.04 mL/ms, P < .05). LA passive and active emptying dV/dt were correlated with LV early and late diastolic dV/dt, respectively (r = 0.47 and r = 0.48, both P < .05). Conclusion: Our 3D echocardiographic study showed that increased LA volume was related to decreased LA contraction in HC. LA passive emptying was related to LV relaxation whereas LA active contraction was related to LV stiffness.

Original languageEnglish (US)
Pages (from-to)796-801
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume19
Issue number6
DOIs
StatePublished - Jun 1 2006

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Relationship Between Left Atrial and Left Ventricular Function in Hypertrophic Cardiomyopathy: A Real-time 3-Dimensional Echocardiographic Study'. Together they form a unique fingerprint.

Cite this