Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali

Bocar Baya; Ibrahim Sanogo; Mahamadou Kone; Dianguina Soumare; Kadidia Ouattara; Amadou Somboro; Mamadou Wague; Nadie Coulibaly; Isaac Koloma; Mariam Coulibaly; Mohamed Nantoume; Mamadou Perou; Kadidia Kone; Djeneba Coulibaly; Hawa Boukary Diarra; Bourahima Kone; Ayouba Diarra; Mamadou D. Coulibaly; Moumine Sanogo; Bassirou Diarra; Mahamadou Diakite; Chad J. Achenbach; Seydou Doumbia; William R. Bishai; Sabra L. Klein; Jane L. Holl; Souleymane Diallo; Robert L. Murphy; Yacouba Toloba; Djeneba Dabitao

doi:10.1016/j.jctube.2023.100389

Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali

Bocar Baya, Ibrahim Sanogo, Mahamadou Kone, Dianguina Soumare, Kadidia Ouattara, Amadou Somboro, Mamadou Wague, Nadie Coulibaly, Isaac Koloma, Mariam Coulibaly, Mohamed Nantoume, Mamadou Perou, Kadidia Kone, Djeneba Coulibaly, Hawa Boukary Diarra, Bourahima Kone, Ayouba Diarra, Mamadou D. Coulibaly, Moumine Sanogo, Bassirou DiarraMahamadou Diakite, Chad J. Achenbach, Seydou Doumbia, William R. Bishai, Sabra L. Klein, Jane L. Holl, Souleymane Diallo, Robert L. Murphy, Yacouba Toloba, Djeneba Dabitao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood. Objective: To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis. Methods: We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined. Results: A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59). Conclusion: Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.

Original language	English (US)
Article number	100389
Journal	Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Volume	33
DOIs	https://doi.org/10.1016/j.jctube.2023.100389
State	Published - Dec 2023

Funding

This project has been supported with funds from the Fogarty International Center (FIC) and the Office of the Director (OD) of the National Institutes of Health (NIH) through the Office of Research on Women’s Health (ORWH), under a Career Development Award K43TW011426 (PI: Dabitao D) and the Institute for Global Health (IGH) Catalyzer Award (MPI: Murphy R and Dabitao D) of the Northwestern University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health nor the Northwestern University. We are thankful to the researchers, clinicians, administrative and support staff of the Department of Pneumophtisiology of the University Teaching Hospital of Point-G in Bamako, Mali. We also thank the personnel of the University Clinical Research Center (UCRC) of the University of Sciences, Techniques, and Technologies of Bamako (USTTB). We are grateful to the study participants. This project has been supported with funds from the Fogarty International Center (FIC) and the Office of the Director (OD) of the National Institutes of Health (NIH) through the Office of Research on Women's Health (ORWH), under a Career Development Award K43TW011426 (PI: Dabitao D) and the Institute for Global Health (IGH) Catalyzer Award (MPI: Murphy R and Dabitao D) of the Northwestern University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health nor the Northwestern University.

Keywords

Africa
Disease
Gender
Localization
Mycobacterium

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jctube.2023.100389

Cite this

Baya, B., Sanogo, I., Kone, M., Soumare, D., Ouattara, K., Somboro, A., Wague, M., Coulibaly, N., Koloma, I., Coulibaly, M., Nantoume, M., Perou, M., Kone, K., Coulibaly, D., Boukary Diarra, H., Kone, B., Diarra, A., Coulibaly, M. D., Sanogo, M., ... Dabitao, D. (2023). Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 33, Article 100389. https://doi.org/10.1016/j.jctube.2023.100389

@article{ae287f3757ac49798e55b2c508fa7e00,

title = "Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali",

abstract = "Background: Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood. Objective: To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis. Methods: We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined. Results: A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59). Conclusion: Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.",

keywords = "Africa, Disease, Gender, Localization, Mycobacterium",

author = "Bocar Baya and Ibrahim Sanogo and Mahamadou Kone and Dianguina Soumare and Kadidia Ouattara and Amadou Somboro and Mamadou Wague and Nadie Coulibaly and Isaac Koloma and Mariam Coulibaly and Mohamed Nantoume and Mamadou Perou and Kadidia Kone and Djeneba Coulibaly and {Boukary Diarra}, Hawa and Bourahima Kone and Ayouba Diarra and Coulibaly, {Mamadou D.} and Moumine Sanogo and Bassirou Diarra and Mahamadou Diakite and Achenbach, {Chad J.} and Seydou Doumbia and Bishai, {William R.} and Klein, {Sabra L.} and Holl, {Jane L.} and Souleymane Diallo and Murphy, {Robert L.} and Yacouba Toloba and Djeneba Dabitao",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = dec,

doi = "10.1016/j.jctube.2023.100389",

language = "English (US)",

volume = "33",

journal = "Journal of Clinical Tuberculosis and Other Mycobacterial Diseases",

issn = "2405-5794",

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Baya, B, Sanogo, I, Kone, M, Soumare, D, Ouattara, K, Somboro, A, Wague, M, Coulibaly, N, Koloma, I, Coulibaly, M, Nantoume, M, Perou, M, Kone, K, Coulibaly, D, Boukary Diarra, H, Kone, B, Diarra, A, Coulibaly, MD, Sanogo, M, Diarra, B, Diakite, M, Achenbach, CJ, Doumbia, S, Bishai, WR, Klein, SL, Holl, JL, Diallo, S, Murphy, RL, Toloba, Y & Dabitao, D 2023, 'Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali', Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, vol. 33, 100389. https://doi.org/10.1016/j.jctube.2023.100389

TY - JOUR

T1 - Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali

AU - Baya, Bocar

AU - Sanogo, Ibrahim

AU - Kone, Mahamadou

AU - Soumare, Dianguina

AU - Ouattara, Kadidia

AU - Somboro, Amadou

AU - Wague, Mamadou

AU - Coulibaly, Nadie

AU - Koloma, Isaac

AU - Coulibaly, Mariam

AU - Nantoume, Mohamed

AU - Perou, Mamadou

AU - Kone, Kadidia

AU - Coulibaly, Djeneba

AU - Boukary Diarra, Hawa

AU - Kone, Bourahima

AU - Diarra, Ayouba

AU - Coulibaly, Mamadou D.

AU - Sanogo, Moumine

AU - Diarra, Bassirou

AU - Diakite, Mahamadou

AU - Achenbach, Chad J.

AU - Doumbia, Seydou

AU - Bishai, William R.

AU - Klein, Sabra L.

AU - Holl, Jane L.

AU - Diallo, Souleymane

AU - Murphy, Robert L.

AU - Toloba, Yacouba

AU - Dabitao, Djeneba

PY - 2023/12

Y1 - 2023/12

N2 - Background: Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood. Objective: To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis. Methods: We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined. Results: A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59). Conclusion: Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.

AB - Background: Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood. Objective: To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis. Methods: We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined. Results: A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59). Conclusion: Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.

KW - Africa

KW - Disease

KW - Gender

KW - Localization

KW - Mycobacterium

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U2 - 10.1016/j.jctube.2023.100389

DO - 10.1016/j.jctube.2023.100389

M3 - Article

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AN - SCOPUS:85167455469

SN - 2405-5794

VL - 33

JO - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

JF - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

M1 - 100389

ER -

Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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