Relationship between peak serum estradiol levels and treatment outcome in in vitro fertilization cycles after embryo transfer on day 3 or day 5

Chi Huang Chen, Xingqi Zhang*, Randall Barnes, Edmond Confino, Magdy Milad, Elizabeth Puscheck, Ralph R. Kazer

*Corresponding author for this work

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Objective: To examine the relationships between peak serum estradiol (E2) levels and treatment outcome in in vitro fertilization (IVF) cycles after embryo transfer (ET) on day 3 or day 5. Design: Retrospective analysis of 697 IVF-ET cycles between January 1999 and December 2001. Setting: A university-affiliated assisted reproduction program. Patient(s): Infertile patients undergoing IVF-ET cycles. Intervention(s): Peak E2 concentration in serum was determined on the day of human chorionic gonadotropin (hCG) administration. The IVF-generated embryos were cultured for 2 days until transfer on day 3. If more than four 8-cell embryos were present on day 3, embryo culture was continued until day 5 for blastocyst transfer. Main outcome measure(s): Clinical pregnancy rates. Result(s): High peak E2 levels did not adversely affect treatment outcome. After the cycles were divided according to the day of ET, high peak E2 levels were associated with improved pregnancy rates after ET on day 5 but not on day 3. Conclusion(s): Increasing peak E2 levels in IVF cycles are associated with improved pregnancy rates after ET on day 5.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalFertility and Sterility
Volume80
Issue number1
DOIs
StatePublished - Jul 1 2003

Keywords

  • Blastocyst transfer
  • Estradiol level in serum
  • Pregnancy rates

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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