Efforts to improve mitral regurgitation (MR) are often performed in conjunction with coronary revascularization. However, the independent effects of reduced MR area (MRa) are difficult to quantify. Using a previously developed cardiovascular model, ventricular contractility (elastance 1-8 mmHg/ml) and relaxation (tau: 40-150 msec) were independently adjusted for 4 grades of MR orifice areas (0.0 to 0.8 cm2). Improvements in forward stroke volume (fSV) were determined for the permutations of reduced MRa. For all conditions, LV end-diastolic pressure and volumes ranged from 7.3-24.2 mmHg and 64.8-174.3 ml, respectively. Overall, fSV ranged from 36.0-89.4 (mean: 64.2±12.8) ml, improved between 6.4 and 35.3% (mean: 15.6±8.1%), and was best predicted by (r=0.97, p<0.01): %Δ(fVS) = 34 [MRainital] - 46 [MRafinal] - 0.5 [elastance]. Reduced MRa, independent of relaxation and minimally influence by contractility, yield improved fSVs.
ASJC Scopus subject areas
- Computer Science Applications
- Cardiology and Cardiovascular Medicine