Relationship of age of onset and family history in Parkinson disease

Matthew J. Barrett; Nicholas E. Hac; Guofen Yan; Madaline B. Harrison; G. Frederick Wooten

doi:10.1002/mds.26166

Relationship of age of onset and family history in Parkinson disease

Matthew J. Barrett^*, Nicholas E. Hac, Guofen Yan, Madaline B. Harrison, G. Frederick Wooten

^*Corresponding author for this work

Research output: Contribution to journal › Letter

6 Scopus citations

Abstract

Background: The aim of this study was to determine whether age of onset of Parkinson disease (PD) is associated with differences in PD risk and PD age of onset in parents and siblings. Methods: Clinical and detailed family history data were available for 1,114 PD probands. Results: Proband age of onset was not associated with differences in PD prevalence or PD age of onset in parents. Proband age of PD onset <50, compared with ≥50 years, was associated with significantly greater risk of PD in siblings (hazard ratio: 2.4; P=0.002; 95% confidence interval: 1.4, 4.1), and proband age of onset was significantly correlated with sibling age of onset (Somer's D=0.20; P=0.018). Conclusions: Proband age of PD onset is not associated with differences in parental PD risk. Siblings of PD patients with onset before age 50 are at increased risk of PD and are more likely to have early-onset disease.

Original language	English (US)
Pages (from-to)	733-735
Number of pages	3
Journal	Movement Disorders
Volume	30
Issue number	5
DOIs	https://doi.org/10.1002/mds.26166
State	Published - Apr 15 2015
Externally published	Yes

Keywords

Age of onset
Familial aggregation
Family history
Genetics
Parkinson disease

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.26166

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title = "Relationship of age of onset and family history in Parkinson disease",

abstract = "Background: The aim of this study was to determine whether age of onset of Parkinson disease (PD) is associated with differences in PD risk and PD age of onset in parents and siblings. Methods: Clinical and detailed family history data were available for 1,114 PD probands. Results: Proband age of onset was not associated with differences in PD prevalence or PD age of onset in parents. Proband age of PD onset <50, compared with ≥50 years, was associated with significantly greater risk of PD in siblings (hazard ratio: 2.4; P=0.002; 95% confidence interval: 1.4, 4.1), and proband age of onset was significantly correlated with sibling age of onset (Somer's D=0.20; P=0.018). Conclusions: Proband age of PD onset is not associated with differences in parental PD risk. Siblings of PD patients with onset before age 50 are at increased risk of PD and are more likely to have early-onset disease.",

keywords = "Age of onset, Familial aggregation, Family history, Genetics, Parkinson disease",

author = "Barrett, {Matthew J.} and Hac, {Nicholas E.} and Guofen Yan and Harrison, {Madaline B.} and Wooten, {G. Frederick}",

year = "2015",

month = apr,

day = "15",

doi = "10.1002/mds.26166",

language = "English (US)",

volume = "30",

pages = "733--735",

journal = "Movement Disorders",

issn = "0885-3185",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Relationship of age of onset and family history in Parkinson disease

AU - Barrett, Matthew J.

AU - Hac, Nicholas E.

AU - Yan, Guofen

AU - Harrison, Madaline B.

AU - Wooten, G. Frederick

PY - 2015/4/15

Y1 - 2015/4/15

N2 - Background: The aim of this study was to determine whether age of onset of Parkinson disease (PD) is associated with differences in PD risk and PD age of onset in parents and siblings. Methods: Clinical and detailed family history data were available for 1,114 PD probands. Results: Proband age of onset was not associated with differences in PD prevalence or PD age of onset in parents. Proband age of PD onset <50, compared with ≥50 years, was associated with significantly greater risk of PD in siblings (hazard ratio: 2.4; P=0.002; 95% confidence interval: 1.4, 4.1), and proband age of onset was significantly correlated with sibling age of onset (Somer's D=0.20; P=0.018). Conclusions: Proband age of PD onset is not associated with differences in parental PD risk. Siblings of PD patients with onset before age 50 are at increased risk of PD and are more likely to have early-onset disease.

AB - Background: The aim of this study was to determine whether age of onset of Parkinson disease (PD) is associated with differences in PD risk and PD age of onset in parents and siblings. Methods: Clinical and detailed family history data were available for 1,114 PD probands. Results: Proband age of onset was not associated with differences in PD prevalence or PD age of onset in parents. Proband age of PD onset <50, compared with ≥50 years, was associated with significantly greater risk of PD in siblings (hazard ratio: 2.4; P=0.002; 95% confidence interval: 1.4, 4.1), and proband age of onset was significantly correlated with sibling age of onset (Somer's D=0.20; P=0.018). Conclusions: Proband age of PD onset is not associated with differences in parental PD risk. Siblings of PD patients with onset before age 50 are at increased risk of PD and are more likely to have early-onset disease.

KW - Age of onset

KW - Familial aggregation

KW - Family history

KW - Genetics

KW - Parkinson disease

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U2 - 10.1002/mds.26166

DO - 10.1002/mds.26166

M3 - Letter

C2 - 25737058

AN - SCOPUS:84927070991

VL - 30

SP - 733

EP - 735

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 5

ER -