Relationship of age of onset and family history in Parkinson disease

Matthew J. Barrett*, Nicholas E. Hac, Guofen Yan, Madaline B. Harrison, G. Frederick Wooten

*Corresponding author for this work

Research output: Contribution to journalLetter

6 Scopus citations

Abstract

Background: The aim of this study was to determine whether age of onset of Parkinson disease (PD) is associated with differences in PD risk and PD age of onset in parents and siblings. Methods: Clinical and detailed family history data were available for 1,114 PD probands. Results: Proband age of onset was not associated with differences in PD prevalence or PD age of onset in parents. Proband age of PD onset <50, compared with ≥50 years, was associated with significantly greater risk of PD in siblings (hazard ratio: 2.4; P=0.002; 95% confidence interval: 1.4, 4.1), and proband age of onset was significantly correlated with sibling age of onset (Somer's D=0.20; P=0.018). Conclusions: Proband age of PD onset is not associated with differences in parental PD risk. Siblings of PD patients with onset before age 50 are at increased risk of PD and are more likely to have early-onset disease.

Original languageEnglish (US)
Pages (from-to)733-735
Number of pages3
JournalMovement Disorders
Volume30
Issue number5
DOIs
StatePublished - Apr 15 2015
Externally publishedYes

Keywords

  • Age of onset
  • Familial aggregation
  • Family history
  • Genetics
  • Parkinson disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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