TY - JOUR
T1 - Relationship of auditory hallucinations and paranoia to platelet MAO activity in schizophrenics
T2 - Sex and race interactions
AU - Meltzer, Herbert Y.
AU - Zureick, Joel L.
N1 - Funding Information:
Acknowledgment. This researchw as supported, in part, by USPHS MH-41594 and MH-41684, by USPHS Research Scientist Award MH-47808 to the first author, and by a grant from the Cleveland Foundation. We gratefully acknowledge the assistanceo f Joseph J. Locascio, Ph.D., Kenneth Prabucki, and Jeff Sharp with the data analyses,a nd Ramesh Arora, Ph.D., and Herbert Jackman, Ph.D., with the biochemical analyses.
PY - 1987/10
Y1 - 1987/10
N2 - Platelet monoamine oxidase (MAO) activity was determined in 37 female and 64 male patients with Research Diagnostic Criteria diagnoses of paranoid or undifferentiated schizophrenia, or schizoaffective disorder, mainly schizophrenic, and for 71 female and 65 male normal controls (NCs). Female NCs had significantly higher adjusted mean platelet MAO activity than male NCs and female, paranoid, nonhallucinating schizophrenics. Male NCs had significantly higher adjusted mean platelet MAO activity than male, paranoid, hallucinating schizophrenics. Examination of main and interactive effects of diagnostic subtype, presence/absence of auditory hallucinations, gender, and race within the group of schizophrenic patients revealed no statistically significant main effect but, rather, significant interactive effects of auditory hallucinations with gender, with diagnostic group and gender, and with diagnostic group and race in the prediction of platelet MAO activity. The interaction of diagnostic subtype with race and gender in the prediction of platelet MAO activity was also statistically significant. In general, significantly decreased platelet MAO activity was associated with both paranoid subtype and presence of auditory hallucinations in male and in black schizophrenics; and with paranoid subtype alone in white male schizophrenics. These interactive relationships with platelet MAO activity in schizophrenics may account for discrepancies in previous reports of the activity of this enzyme in schizophrenics, and are consistent with reduced platelet MAO activity in subgroups of schizophrenics.
AB - Platelet monoamine oxidase (MAO) activity was determined in 37 female and 64 male patients with Research Diagnostic Criteria diagnoses of paranoid or undifferentiated schizophrenia, or schizoaffective disorder, mainly schizophrenic, and for 71 female and 65 male normal controls (NCs). Female NCs had significantly higher adjusted mean platelet MAO activity than male NCs and female, paranoid, nonhallucinating schizophrenics. Male NCs had significantly higher adjusted mean platelet MAO activity than male, paranoid, hallucinating schizophrenics. Examination of main and interactive effects of diagnostic subtype, presence/absence of auditory hallucinations, gender, and race within the group of schizophrenic patients revealed no statistically significant main effect but, rather, significant interactive effects of auditory hallucinations with gender, with diagnostic group and gender, and with diagnostic group and race in the prediction of platelet MAO activity. The interaction of diagnostic subtype with race and gender in the prediction of platelet MAO activity was also statistically significant. In general, significantly decreased platelet MAO activity was associated with both paranoid subtype and presence of auditory hallucinations in male and in black schizophrenics; and with paranoid subtype alone in white male schizophrenics. These interactive relationships with platelet MAO activity in schizophrenics may account for discrepancies in previous reports of the activity of this enzyme in schizophrenics, and are consistent with reduced platelet MAO activity in subgroups of schizophrenics.
KW - Schizophrenia
KW - auditory hallucinations
KW - monoamine oxidase
KW - paranoia
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U2 - 10.1016/0165-1781(87)90097-7
DO - 10.1016/0165-1781(87)90097-7
M3 - Article
C2 - 3685225
AN - SCOPUS:0023281014
VL - 22
SP - 99
EP - 109
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 2
ER -