Relationship of diastolic intraventricular pressure gradients and aerobic capacity in patients with diastolic heart failure

Aleksandr Rovner, Neil L. Greenberg*, James D. Thomas, Mario J. Garcia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


We sought to elucidate the relationship between diastolic intraventricular pressure gradients (IVPG) and exercise tolerance in patients with heart failure using color M-mode Doppler. Diastolic dysfunction has been implicated as a cause of low aerobic potential in patients with heart failure. We previously validated a novel method to evaluate diastolic function that involves noninvasive measurement of IVPG using color M-mode Doppler data. Thirty-one patients with heart failure and 15 normal subjects were recruited. Echocardiograms were performed before and after metabolic treadmill stress testing. Color M-mode Doppler was used to determine the diastolic propagation velocity (Vp) and IVPG off-line. Resting diastolic function indexes including myocardial relaxation velocity, Vp, and E/Vp correlated well with Vo2 max (r = 0.8, 0.5, and -0.5, respectively, P < 0.001 for all). There was a statistically significant increase in V p and IVPG in both groups after exercise, but the change in IVPG was higher in normal subjects compared with patients with heart failure (2.6 ± 0.8 vs. 1.1 ± 0.8 mmHg, P < 0.05). Increase in IVPG correlated with peak Vo2 max (r = 0.8, P < 0.001) and was the strongest predictor of exercise capacity. Myocardial relaxation is an important determinant of exercise aerobic capacity. In heart failure patients, impaired myocardial relaxation is associated with reduced diastolic suction force during exercise.

Original languageEnglish (US)
Pages (from-to)H2081-H2088
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number5 58-5
StatePublished - Nov 2005


  • Cardiovascular system
  • Metabolic stress test
  • Oxygen metabolism

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Relationship of diastolic intraventricular pressure gradients and aerobic capacity in patients with diastolic heart failure'. Together they form a unique fingerprint.

Cite this