TY - JOUR
T1 - Relationship of Movement Disorders Society–Unified Parkinson's Disease Rating Scale Nonmotor Symptoms to Cognitive Functioning in Patients with Parkinson's Disease
AU - Bernard, Bryan A.
AU - Carns, Danielle
AU - Stebbins, Glenn T.
AU - Goldman, Jennifer G.
AU - Goetz, Christopher G.
N1 - Funding Information:
B.A.B. and D.C. have nothing to disclose. G.T.S. has consulting and advisory board membership with honoraria from Acadia, Pharmaceuticals, Adamas Pharmaceuticals, Inc., Biogen, Inc., Ceregene, Inc., CHDI Management, Inc., Cleveland Clinic Foundation, Ingenix Pharmaceutical Services (i3 Research), MedGenesis Therapeutix, Inc., Neurocrine Biosciences, Inc., Pfizer, Inc., Tools‐4‐Patients, Ultragenyx, Inc., and Sunshine Care Foundation. Grants and research funding include the National Institutes of Health, Department of Defense, Michael J. Fox Foundation for Parkinson's Research, Dystonia Coalition, CHDI, Cleveland Clinic Foundation, International Parkinson and Movement Disorder Society, and CBD Solutions. Dr. Stebbins receives honoraria from the International Parkinson and Movement Disorder Society, American Academy of Neurology, Michael J. Fox Foundation for Parkinson's Research, Food and Drug Administration, National Institutes of Health, and the Alzheimer's Association. J.G.G. has received grant and research support from the National Institutes of Health, Michael J. Fox Foundation, Rush University, Acadia, CHDI, and Parkinson's Foundation. Dr. Goldman has received consulting fees from Acadia, Aptinyx, Sunovion, and Worldwide Med and honoraria from the International Parkinson and Movement Disorder Society, American Academy of Neurology, and Parkinson's Foundation. C.G.G. has consulting or advisory board membership with honoraria from Boston Scientific and Oxford Biomedica. Grants and research funding include Rush University Medical Center from the National Institutes of Health and Michael J. Fox Foundation for research conducted by Dr. Goetz. Dr. Goetz directs the Rush Parkinson's Disease Research Center that receives support from the Parkinson's Disease Foundation, and some of these funds support Dr. Goetz's salary as well as his research efforts. He participated in the directorship of the translation program for the Movement Disorders Society–Unified Parkinson's Disease Rating Scale and Unified Dyskinesia Rating Scale and received funds directed to Rush University Medical Center from the International Parkinson and Movement Disorder Society for this effort. He receives honoraria from a Presidential stipend from the International Parkinson and Movement Disorder Society paid to Rush University Medical Center as part of Dr. Goetz's salary and a faculty stipend from the International Parkinson and Movement Disorder Society. Financial Disclosures for the Previous 12 Months:
Publisher Copyright:
© 2020 International Parkinson and Movement Disorder Society
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Background: Few studies assess the relationships between nonmotor aspects of experiences of daily living and cognitive functioning in Parkinson's disease (PD). Objective: To evaluate the relationships among the Movement Disorders Society–Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part I items and neuropsychological tests in PD.Methods: We assessed 151 PD patients with the MDS-UPDRS part I and a battery of cognitive tests focused on the following 5 cognitive domains: attention/working memory, executive functioning, recent memory, language, visuoperception. Raw scores for individual cognitive tests were transformed to z scores, and cognitive domain scores were calculated by averaging z scores within each domain. Individual items from the MDS-UPDRS part I were entered in a stepwise linear regression analysis assessing item contribution to cognitive domain scores. Results: The MDS-UPDRS part I item scores for hallucinations and psychosis and light headedness on standing predicted attention/working memory domain scores (P = 0.004). These same item scores, along with apathy, depressed mood, and dopamine dysregulation syndrome, predicted executive functioning (P = 0.044). The apathy and dopamine dysregulation syndrome items predicted language (P = 0.006). In addition, the cognitive impairment and sleep items were predictors of recent memory (P = 0.031). None of the items were predictors of visuoperception (P = 0.006). Other part I items were not significantly related to cognitive domain scores. Conclusions: Specific nonmotor MDS-UPDRS part I items, particularly mood, behavior, and autonomic-related items, exhibited significant relationships with cognitive domains. The highest number of items were predictive of the executive functioning domain, which is the hallmark cognitive dysfunction in PD.
AB - Background: Few studies assess the relationships between nonmotor aspects of experiences of daily living and cognitive functioning in Parkinson's disease (PD). Objective: To evaluate the relationships among the Movement Disorders Society–Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part I items and neuropsychological tests in PD.Methods: We assessed 151 PD patients with the MDS-UPDRS part I and a battery of cognitive tests focused on the following 5 cognitive domains: attention/working memory, executive functioning, recent memory, language, visuoperception. Raw scores for individual cognitive tests were transformed to z scores, and cognitive domain scores were calculated by averaging z scores within each domain. Individual items from the MDS-UPDRS part I were entered in a stepwise linear regression analysis assessing item contribution to cognitive domain scores. Results: The MDS-UPDRS part I item scores for hallucinations and psychosis and light headedness on standing predicted attention/working memory domain scores (P = 0.004). These same item scores, along with apathy, depressed mood, and dopamine dysregulation syndrome, predicted executive functioning (P = 0.044). The apathy and dopamine dysregulation syndrome items predicted language (P = 0.006). In addition, the cognitive impairment and sleep items were predictors of recent memory (P = 0.031). None of the items were predictors of visuoperception (P = 0.006). Other part I items were not significantly related to cognitive domain scores. Conclusions: Specific nonmotor MDS-UPDRS part I items, particularly mood, behavior, and autonomic-related items, exhibited significant relationships with cognitive domains. The highest number of items were predictive of the executive functioning domain, which is the hallmark cognitive dysfunction in PD.
KW - Parkinson's disease
KW - nonmotor symptoms
UR - http://www.scopus.com/inward/record.url?scp=85079408384&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85079408384&partnerID=8YFLogxK
U2 - 10.1002/mdc3.12902
DO - 10.1002/mdc3.12902
M3 - Article
C2 - 32258225
AN - SCOPUS:85079408384
VL - 7
SP - 279
EP - 283
JO - Movement Disorders Clinical Practice
JF - Movement Disorders Clinical Practice
SN - 2330-1619
IS - 3
ER -