Relationships among allergic rhinitis, asthma, and chronic rhinosinusitis

Mariel G. Rosati, Anju T. Peters*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Background: Chronic rhinosinusitis (CRS) is a common disease in the United States. There are a significant number of patients with CRS who are refractory to standard medical and surgical therapy. Many of these patients also have comorbid allergic rhinitis (AR) and asthma, although the underlying pathophysiology that connects these three conditions remains unclear. Objective: The goal of this article is to review the relationships among CRS, AR and asthma. Methods: Scientific literature that addresses the prevalence of AR and asthma in CRS populations, the effect of AR and asthma on CRS disease severity, and whether treatment of AR and asthma can affect CRS outcomes was reviewed. Results: The literature supports the relationship between AR and CRS, but there is no direct evidence of causality the between the two conditions. There is a high prevalence of CRS in patients with asthma and the presence of CRS is associated with worse asthma outcomes. There is weak evidence that treatment of CRS may improve asthma outcomes. Targeting type 2 inflammation via biologics is being investigated in the treatment of asthma and CRS. Conclusion: AR, asthma, and CRS are closed related and understanding the associations among these comorbid diseases will have significant clinical implication.

Original languageEnglish (US)
Pages (from-to)44-47
Number of pages4
JournalAmerican Journal of Rhinology and Allergy
Volume30
Issue number1
DOIs
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

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