Relationships among cerebrospinal fluid biomarkers in dementia of the Alzheimer type

John G. Csernansky*, J. Philip Miller, Daniel McKeel, John C. Morris

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Cerebrospinal fluid (CSF) contains proteins known to be involved in the pathogenesis of Alzheimer disease (AD), including amyloid-related proteins, tau protein and apolipoprotein E. While the CSF concentrations of these proteins have been compared in subjects with and without dementia of the Alzheimer type (DAT), they have not been simultaneously assessed in carefully staged DAT subjects and control subjects to examine correlations among them. In this study, CSF concentrations of soluble amyloid precursor protein (sAPP), two forms of β-amyloid protein (Aβtotal and Aβ1-42), tau, and apolipoprotein E were assessed in subjects with (n = 33) and without (n = 11) DAT. Direct correlations were found between CSF concentrations of sAPP and tau and Aβtotal, and between apolipoprotein E and Aβtotal within the DAT subjects and within the combined group of DAT and control subjects. A weak inverse correlation was also found between CSF concentrations of tau and Aβ1-42 within the combined group of DAT and control subjects. Moreover, increased severity of dementia was correlated with increased CSF tau concentrations and decreased sAPP and Aβtotal concentrations. Increased CSF concentrations of tau significantly discriminated DAT and control subjects, as did the ratios of tau to Aβtotal and tau to Aβ1-42.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalAlzheimer Disease and Associated Disorders
Volume16
Issue number3
DOIs
StatePublished - Jul 2002

Keywords

  • Alzheimer disease
  • Apolipoprotein E
  • Cerebrospinal fluid
  • Tau protein
  • β-amyloid protein

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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