@article{0107900271df460e870700861347dbc5,
title = "Relationships among tau burden, atrophy, age, and naming in the aphasic variant of Alzheimer's disease",
abstract = "Introduction: Examination of pathologic, anatomic, and cognitive relationships has been limited in primary progressive aphasia (PPA) with underlying Alzheimer's disease (AD) neuropathology. Methods: Spatial relationships between tau positron emission tomography (PET), cortical thickness, age, and naming on the Boston Naming Test (BNT) in PPA with biomarker evidence of AD (PPA-AD) were examined. Results: Higher tau PET burden was associated with atrophy and younger age. There was a significant left-lateralized relationship between lower BNT and more atrophy, and between lower BNT and increased tau burden. Variance in naming was primarily shared between tau and atrophy (51%), but naming was uniquely explained more by atrophy (32%) than tau (16%). Higher left anterior temporal tau burden was associated with greater 1-year rate of decline in naming. Discussion: PPA-AD has a similar relationship between abnormal biomarkers as first described in amnestic AD, with differing spatial extent, reflecting the left-lateralized nature of the language network.",
keywords = "AV-1451, atrophy, cortical thickness, magnetic resonance imaging, naming, positron emission tomography, primary progressive aphasia, tau positron emission tomography, volumetric magnetic resonance imaging",
author = "Adam Martersteck and Jaiashre Sridhar and Christina Coventry and Sandra Weintraub and Mesulam, {M. Marsel} and Emily Rogalski",
note = "Funding Information: We would like to thank Benjamin Rader, Stacey Moeller, Rhiana Schafer, Emmaleigh Loyer, Maureen Connelly, and Marie Saxon for neuropsychological test administration of the participants; Fatima Eldes, Iktae Kim, and Jessica Wood for their assistance with FreeSurfer MRI processing; Scott Leonard for his assistance with PET imaging, performed at Northwestern University Department of Nuclear Medicine; Dr. Todd Parrish and Dr. Yu Fen Chen for MR imaging, performed at the Northwestern University Department of Radiology Center for Translational Imaging. Image processing was supported by the Quest high performance computing cluster provided by Northwestern University, Department of Information Technology, Office for Research, and Office of the Provost. Avid Radiopharmaceuticals provided the 18F-florbetapir and 18F-flortaucipir PET ligands (to E.R.). Life Molecular Imaging provided the 18F-florbetaben PET ligands (to E.R.). Neither company was involved in data analysis or interpretation. This research was supported by NIH grants: R01DC008552 from the National Institute on Deafness and Other Communication Disorders; P30AG013854, T32AG020506, and R01AG056258 from the National Institute on Aging; R01NS075075 from the National Institute of Neurological Disorders and Stroke. Funding Information: We would like to thank Benjamin Rader, Stacey Moeller, Rhiana Schafer, Emmaleigh Loyer, Maureen Connelly, and Marie Saxon for neuropsychological test administration of the participants; Fatima Eldes, Iktae Kim, and Jessica Wood for their assistance with FreeSurfer MRI processing; Scott Leonard for his assistance with PET imaging, performed at Northwestern University Department of Nuclear Medicine; Dr. Todd Parrish and Dr. Yu Fen Chen for MR imaging, performed at the Northwestern University Department of Radiology Center for Translational Imaging. Image processing was supported by the Quest high performance computing cluster provided by Northwestern University, Department of Information Technology, Office for Research, and Office of the Provost. Avid Radiopharmaceuticals provided the F‐florbetapir and F‐flortaucipir PET ligands (to E.R.). Life Molecular Imaging provided the F‐florbetaben PET ligands (to E.R.). Neither company was involved in data analysis or interpretation. This research was supported by NIH grants: R01DC008552 from the National Institute on Deafness and Other Communication Disorders; P30AG013854, T32AG020506, and R01AG056258 from the National Institute on Aging; R01NS075075 from the National Institute of Neurological Disorders and Stroke. 18 18 18 Publisher Copyright: {\textcopyright} 2021 the Alzheimer's Association",
year = "2021",
month = nov,
doi = "10.1002/alz.12445",
language = "English (US)",
volume = "17",
pages = "1788--1797",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "11",
}
