Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures

William A. Paxton*, Scott R. Martin, Doris Tse, Thomas R. O'Brien, Joan Skurnick, Nancy L. VanDevanter, Nancy Padian, James F. Braun, Donald P. Kotler, Steven M. Wolinsky, Richard A. Koup

*Corresponding author for this work

Research output: Contribution to journalArticle

569 Scopus citations

Abstract

Some individuals remain uninfected with human immunodeficiency virus type- 1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocytes from nonexposed controls. Further studies indicated that their purified CD4+ lymphocytes were less susceptible to infection with multiple primary isolates of HIV-1 than were CD4+ lymphocytes from the nonexposed controls. This relative resistance to HIV-1 infection did not extend to T-cell line-adapted strains, was restricted by the envelope glycoprotein, was not explained by the cell surface density of CD4 molecules, but was associated with the aCtivity of the C-C chemokines RANTES, MIP-1α, and MIP-1β. This relative resistance of CD4+ lymphocytes may contribute to protection from HIV-1 in multiply exposed persons.

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalNature Medicine
Volume2
Issue number4
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Paxton, W. A., Martin, S. R., Tse, D., O'Brien, T. R., Skurnick, J., VanDevanter, N. L., Padian, N., Braun, J. F., Kotler, D. P., Wolinsky, S. M., & Koup, R. A. (1996). Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nature Medicine, 2(4), 412-417. https://doi.org/10.1038/nm0496-412