Relaxant action of Plumula Nelumbinis extract on mouse airway smooth muscle

Li Tan, Weiwei Chen, Ming Yu Wei, Jinhua Shen, Meng Fei Yu, Guangzhong Yang, Donglin Guo, Gangjian Qin, Guangju Ji, Qing Hua Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca2+ channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.

Original languageEnglish (US)
Article number523640
JournalEvidence-based Complementary and Alternative Medicine
Volume2015
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Complementary and alternative medicine

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