Relaxant action of Plumula Nelumbinis extract on mouse airway smooth muscle

Li Tan; Weiwei Chen; Ming Yu Wei; Jinhua Shen; Meng Fei Yu; Guangzhong Yang; Donglin Guo; Gangjian Qin; Guangju Ji; Qing Hua Liu

doi:10.1155/2015/523640

Relaxant action of Plumula Nelumbinis extract on mouse airway smooth muscle

Li Tan, Weiwei Chen, Ming Yu Wei, Jinhua Shen, Meng Fei Yu, Guangzhong Yang, Donglin Guo, Gangjian Qin, Guangju Ji, Qing Hua Liu^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K⁺ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca²⁺ channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca²⁺ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.

Original language	English (US)
Article number	523640
Journal	Evidence-based Complementary and Alternative Medicine
Volume	2015
DOIs	https://doi.org/10.1155/2015/523640
State	Published - 2015

ASJC Scopus subject areas

Complementary and alternative medicine

Access to Document

10.1155/2015/523640

Cite this

@article{dab8b082ee084713bc4ef47979426fb7,

title = "Relaxant action of Plumula Nelumbinis extract on mouse airway smooth muscle",

abstract = "The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca2+ channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.",

author = "Li Tan and Weiwei Chen and Wei, {Ming Yu} and Jinhua Shen and Yu, {Meng Fei} and Guangzhong Yang and Donglin Guo and Gangjian Qin and Guangju Ji and Liu, {Qing Hua}",

note = "Publisher Copyright: {\textcopyright} 2015 Li Tan et al.",

year = "2015",

doi = "10.1155/2015/523640",

language = "English (US)",

volume = "2015",

journal = "Evidence-based Complementary and Alternative Medicine",

issn = "1741-427X",

publisher = "Hindawi Limited",

}

TY - JOUR

T1 - Relaxant action of Plumula Nelumbinis extract on mouse airway smooth muscle

AU - Tan, Li

AU - Chen, Weiwei

AU - Wei, Ming Yu

AU - Shen, Jinhua

AU - Yu, Meng Fei

AU - Yang, Guangzhong

AU - Guo, Donglin

AU - Qin, Gangjian

AU - Ji, Guangju

AU - Liu, Qing Hua

PY - 2015

Y1 - 2015

N2 - The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca2+ channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.

AB - The traditional herb Plumula Nelumbinis is widely used in the world because it has many biological activities, such as anti-inflammation, antioxidant, antihypertension, and butyrylcholinesterase inhibition. However, the action of Plumula Nelumbinis on airway smooth muscle (ASM) relaxation has not been investigated. A chloroform extract of Plumula Nelumbinis (CEPN) was prepared, which completely inhibited precontraction induced by high K+ in a concentration-dependent manner in mouse tracheal rings, but it had no effect on resting tension. CEPN also blocked voltage-dependent L-type Ca2+ channel- (VDCC-) mediated currents. In addition, ACh-induced precontraction was also completely blocked by CEPN and partially inhibited by nifedipine or pyrazole 3. Besides, CEPN partially reduced ACh-activated nonselective cation channel (NSCC) currents. Taken together, our data demonstrate that CEPN blocked VDCC and NSCC to inhibit Ca2+ influx, resulting in relaxation of precontracted ASM. This finding indicates that CEPN would be a candidate of new potent bronchodilators.

UR - http://www.scopus.com/inward/record.url?scp=84924194534&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924194534&partnerID=8YFLogxK

U2 - 10.1155/2015/523640

DO - 10.1155/2015/523640

M3 - Article

C2 - 25763092

AN - SCOPUS:84924194534

SN - 1741-427X

VL - 2015

JO - Evidence-based Complementary and Alternative Medicine

JF - Evidence-based Complementary and Alternative Medicine

M1 - 523640

ER -

Relaxant action of Plumula Nelumbinis extract on mouse airway smooth muscle

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this