Release and effects of ATP and its derivatives at cholinergic synapses

Eugene M. Silinsky; Timothy J. Searl; Renee S. Redman; Jody K. Hirsh

doi:10.1002/ddr.1095

Release and effects of ATP and its derivatives at cholinergic synapses

Eugene M. Silinsky^*, Timothy J. Searl, Renee S. Redman, Jody K. Hirsh

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

ATP is released from many central and peripheral terminals in a rapid, synchronous manner. It can act both as a neurotransmitter substance and as a neuromodulator in conjunction with a primary neurotransmitter. We begin this perspective by reviewing the evidence for the quantal release of ATP together with acetylcholine (ACh) from motor nerve endings. Next, we discuss the inhibitory effects of adenosine derivatives on presynaptic and postsynaptic membranes at cholinergic synapses. With regard to the presynaptic effects of adenosine, after hydrolysis to adenosine ATP is the mediator of skeletal neuromuscular depression at low frequencies of stimulation. The evidence confirming the suggestion that this inhibitory effect of adenosine at motor nerve endings is mediated downstream of calcium entry is presented. Finally, the data showing the mutually occlusive effects of ATP and ACh at cholinoceptive neurons are summarized and discussed.

Original language	English (US)
Pages (from-to)	22-33
Number of pages	12
Journal	Drug Development Research
Volume	52
Issue number	1-2
DOIs	https://doi.org/10.1002/ddr.1095
State	Published - 2001

Keywords

Neuromuscular junction
Nicotinic
Purinergic
Receptors
Synaptic

ASJC Scopus subject areas

Drug Discovery

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10.1002/ddr.1095

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title = "Release and effects of ATP and its derivatives at cholinergic synapses",

abstract = "ATP is released from many central and peripheral terminals in a rapid, synchronous manner. It can act both as a neurotransmitter substance and as a neuromodulator in conjunction with a primary neurotransmitter. We begin this perspective by reviewing the evidence for the quantal release of ATP together with acetylcholine (ACh) from motor nerve endings. Next, we discuss the inhibitory effects of adenosine derivatives on presynaptic and postsynaptic membranes at cholinergic synapses. With regard to the presynaptic effects of adenosine, after hydrolysis to adenosine ATP is the mediator of skeletal neuromuscular depression at low frequencies of stimulation. The evidence confirming the suggestion that this inhibitory effect of adenosine at motor nerve endings is mediated downstream of calcium entry is presented. Finally, the data showing the mutually occlusive effects of ATP and ACh at cholinoceptive neurons are summarized and discussed.",

keywords = "Neuromuscular junction, Nicotinic, Purinergic, Receptors, Synaptic",

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TY - JOUR

T1 - Release and effects of ATP and its derivatives at cholinergic synapses

AU - Silinsky, Eugene M.

AU - Searl, Timothy J.

AU - Redman, Renee S.

AU - Hirsh, Jody K.

PY - 2001

Y1 - 2001

N2 - ATP is released from many central and peripheral terminals in a rapid, synchronous manner. It can act both as a neurotransmitter substance and as a neuromodulator in conjunction with a primary neurotransmitter. We begin this perspective by reviewing the evidence for the quantal release of ATP together with acetylcholine (ACh) from motor nerve endings. Next, we discuss the inhibitory effects of adenosine derivatives on presynaptic and postsynaptic membranes at cholinergic synapses. With regard to the presynaptic effects of adenosine, after hydrolysis to adenosine ATP is the mediator of skeletal neuromuscular depression at low frequencies of stimulation. The evidence confirming the suggestion that this inhibitory effect of adenosine at motor nerve endings is mediated downstream of calcium entry is presented. Finally, the data showing the mutually occlusive effects of ATP and ACh at cholinoceptive neurons are summarized and discussed.

AB - ATP is released from many central and peripheral terminals in a rapid, synchronous manner. It can act both as a neurotransmitter substance and as a neuromodulator in conjunction with a primary neurotransmitter. We begin this perspective by reviewing the evidence for the quantal release of ATP together with acetylcholine (ACh) from motor nerve endings. Next, we discuss the inhibitory effects of adenosine derivatives on presynaptic and postsynaptic membranes at cholinergic synapses. With regard to the presynaptic effects of adenosine, after hydrolysis to adenosine ATP is the mediator of skeletal neuromuscular depression at low frequencies of stimulation. The evidence confirming the suggestion that this inhibitory effect of adenosine at motor nerve endings is mediated downstream of calcium entry is presented. Finally, the data showing the mutually occlusive effects of ATP and ACh at cholinoceptive neurons are summarized and discussed.

KW - Neuromuscular junction

KW - Nicotinic

KW - Purinergic

KW - Receptors

KW - Synaptic

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JO - Drug Development Research

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ER -

Release and effects of ATP and its derivatives at cholinergic synapses

Abstract

Keywords

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