TY - JOUR
T1 - Relevance of proto-oncogenes as growth modulators in organogenesis of the mammalian embryonic kidney
AU - Kumar, Anil
AU - Wallner, Elisabeth I.
AU - Carone, Frank A.
AU - Scarpelli, Dante G.
AU - Kanwar, Yashpal S.
PY - 1997/10
Y1 - 1997/10
N2 - During embryonic life, renal morphogenesis is characterized by a defined period of intense cellular activity, inductive-transformation of undifferentiated cells to polarized epithelial, in-growth of capillaries into an intricate parenchymal epithelial-mesenchymal mass, and finally the maturation into an organ with diverse structural and biological functions. It should be emphasized that the interactions between various proto-oncogenes, serving as receptors, and the growth factors and other morphogenetic modulators, e.g., ECM glycoproteins, are required for proper epithelial- mesenchymal interactions essential to the process of nephrogenesis. A 'balance' between the activities of these diverse group of macromolecules, whether essential or redundant, is needed to orchestrate the proper cell signals and proliferative responses to assure the progression of normal organogenesis (Pardee, 1987). Finally, in spite of the enormous wealth of data in the literature, the process of renal development is so complex that a clear picture has yet to emerge of the precisely coordinated sequential events that result in the formation of the mature functioning kidney.
AB - During embryonic life, renal morphogenesis is characterized by a defined period of intense cellular activity, inductive-transformation of undifferentiated cells to polarized epithelial, in-growth of capillaries into an intricate parenchymal epithelial-mesenchymal mass, and finally the maturation into an organ with diverse structural and biological functions. It should be emphasized that the interactions between various proto-oncogenes, serving as receptors, and the growth factors and other morphogenetic modulators, e.g., ECM glycoproteins, are required for proper epithelial- mesenchymal interactions essential to the process of nephrogenesis. A 'balance' between the activities of these diverse group of macromolecules, whether essential or redundant, is needed to orchestrate the proper cell signals and proliferative responses to assure the progression of normal organogenesis (Pardee, 1987). Finally, in spite of the enormous wealth of data in the literature, the process of renal development is so complex that a clear picture has yet to emerge of the precisely coordinated sequential events that result in the formation of the mature functioning kidney.
KW - Extracellular matrix
KW - Growth factors
KW - Proto-oncogenes
KW - Renal development
KW - Suppressor genes
KW - Transcription factors
UR - http://www.scopus.com/inward/record.url?scp=0030657581&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030657581&partnerID=8YFLogxK
M3 - Review article
C2 - 9415484
AN - SCOPUS:0030657581
SN - 0214-6282
VL - 41
SP - 643
EP - 653
JO - International Journal of Developmental Biology
JF - International Journal of Developmental Biology
IS - 5
ER -