Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy

Lin Sun; Yashpal S. Kanwar

doi:10.1038/ki.2015.250

Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy

Lin Sun^*, Yashpal S. Kanwar

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Comment/debate › peer-review

88 Scopus citations

Abstract

An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical microinflammation with influx of macrophages and consequent generation of myriad proinflammatory cytokines and ensuing kidney damage. Among various proinflammatory cytokines, tumor necrosis factor-α (TNF-α) has attracted the most attention, since it amplifies the inflammatory network of cytokines, leading to worsening of the progression of diabetic nephropathy. The article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.

Original language	English (US)
Pages (from-to)	662-665
Number of pages	4
Journal	Kidney international
Volume	88
Issue number	4
DOIs	https://doi.org/10.1038/ki.2015.250
State	Published - Oct 3 2015

Funding

Supported in part by US National Institutes of Health grant DK60635 and the National Science Foundation of China.

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ki.2015.250

Cite this

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abstract = "An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical microinflammation with influx of macrophages and consequent generation of myriad proinflammatory cytokines and ensuing kidney damage. Among various proinflammatory cytokines, tumor necrosis factor-α (TNF-α) has attracted the most attention, since it amplifies the inflammatory network of cytokines, leading to worsening of the progression of diabetic nephropathy. The article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.",

author = "Lin Sun and Kanwar, {Yashpal S.}",

note = "Funding Information: Supported in part by US National Institutes of Health grant DK60635 and the National Science Foundation of China.",

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N2 - An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical microinflammation with influx of macrophages and consequent generation of myriad proinflammatory cytokines and ensuing kidney damage. Among various proinflammatory cytokines, tumor necrosis factor-α (TNF-α) has attracted the most attention, since it amplifies the inflammatory network of cytokines, leading to worsening of the progression of diabetic nephropathy. The article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.

AB - An ancillary paradigm that has evolved recently in the pathogenesis of diabetic nephropathy includes subclinical microinflammation with influx of macrophages and consequent generation of myriad proinflammatory cytokines and ensuing kidney damage. Among various proinflammatory cytokines, tumor necrosis factor-α (TNF-α) has attracted the most attention, since it amplifies the inflammatory network of cytokines, leading to worsening of the progression of diabetic nephropathy. The article by Awad et al. examines the role of TNF-α in the pathogenesis of experimental diabetic nephropathy.

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Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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