Reliability and construct validity of PROMIS® measures for patients with heart failure who undergo heart transplant

Kathryn E. Flynn, Mary Amanda Dew, Li Lin, Maria Fawzy, Felicia L. Graham, Elizabeth A Hahn, Ron D. Hays, Robert L. Kormos, Honghu Liu, Mary McNulty, Kevin P. Weinfurt

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Purpose: To evaluate the reliability and construct validity of measures from the Patient-Reported Outcomes Measurement Information System® (PROMIS®) for patients with heart failure before and after heart transplantation. Methods: We assessed reliability of the PROMIS short forms using Cronbach’s alpha and the average marginal reliability. To assess the construct validity of PROMIS computerized adaptive tests and short-form measures, we calculated Pearson product moment correlations between PROMIS measures of physical function, fatigue, depression, and social function and existing PRO measures of similar domains (i.e., convergent validity) as well as different domains (i.e., discriminate validity) in patients with heart failure awaiting heart transplant. We evaluated the responsiveness of these measures to change after heart transplant using effect sizes. Results: Forty-eight patients were included in the analyses. Across the many domains examined, correlations between conceptually similar domains were larger than correlations between different domains of health, demonstrating construct validity. Health status improved substantially after heart transplant (standardized effect sizes, 0.63–1.24), demonstrating the responsiveness of the PROMIS measures. Scores from the computerized adaptive tests and the short forms were similar. Conclusions: This study provides evidence for the reliability and construct validity (including responsiveness to change) of four PROMIS domains in patients with heart failure before and after heart transplant. PROMIS measures are a reasonable choice in this context and will facilitate comparisons across studies and health conditions.

Original languageEnglish (US)
Pages (from-to)2591-2599
Number of pages9
JournalQuality of Life Research
Volume24
Issue number11
DOIs
StatePublished - Nov 1 2015

Fingerprint

Information Systems
Reproducibility of Results
Heart Failure
Transplants
Health
Heart Transplantation
Patient Reported Outcome Measures
Health Status
Fatigue

Keywords

  • Congestive heart failure
  • Outcomes research
  • Patient-reported outcomes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Flynn, Kathryn E. ; Dew, Mary Amanda ; Lin, Li ; Fawzy, Maria ; Graham, Felicia L. ; Hahn, Elizabeth A ; Hays, Ron D. ; Kormos, Robert L. ; Liu, Honghu ; McNulty, Mary ; Weinfurt, Kevin P. / Reliability and construct validity of PROMIS® measures for patients with heart failure who undergo heart transplant. In: Quality of Life Research. 2015 ; Vol. 24, No. 11. pp. 2591-2599.
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Flynn, KE, Dew, MA, Lin, L, Fawzy, M, Graham, FL, Hahn, EA, Hays, RD, Kormos, RL, Liu, H, McNulty, M & Weinfurt, KP 2015, 'Reliability and construct validity of PROMIS® measures for patients with heart failure who undergo heart transplant', Quality of Life Research, vol. 24, no. 11, pp. 2591-2599. https://doi.org/10.1007/s11136-015-1010-y

Reliability and construct validity of PROMIS® measures for patients with heart failure who undergo heart transplant. / Flynn, Kathryn E.; Dew, Mary Amanda; Lin, Li; Fawzy, Maria; Graham, Felicia L.; Hahn, Elizabeth A; Hays, Ron D.; Kormos, Robert L.; Liu, Honghu; McNulty, Mary; Weinfurt, Kevin P.

In: Quality of Life Research, Vol. 24, No. 11, 01.11.2015, p. 2591-2599.

Research output: Contribution to journalArticle

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T1 - Reliability and construct validity of PROMIS® measures for patients with heart failure who undergo heart transplant

AU - Flynn, Kathryn E.

AU - Dew, Mary Amanda

AU - Lin, Li

AU - Fawzy, Maria

AU - Graham, Felicia L.

AU - Hahn, Elizabeth A

AU - Hays, Ron D.

AU - Kormos, Robert L.

AU - Liu, Honghu

AU - McNulty, Mary

AU - Weinfurt, Kevin P.

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N2 - Purpose: To evaluate the reliability and construct validity of measures from the Patient-Reported Outcomes Measurement Information System® (PROMIS®) for patients with heart failure before and after heart transplantation. Methods: We assessed reliability of the PROMIS short forms using Cronbach’s alpha and the average marginal reliability. To assess the construct validity of PROMIS computerized adaptive tests and short-form measures, we calculated Pearson product moment correlations between PROMIS measures of physical function, fatigue, depression, and social function and existing PRO measures of similar domains (i.e., convergent validity) as well as different domains (i.e., discriminate validity) in patients with heart failure awaiting heart transplant. We evaluated the responsiveness of these measures to change after heart transplant using effect sizes. Results: Forty-eight patients were included in the analyses. Across the many domains examined, correlations between conceptually similar domains were larger than correlations between different domains of health, demonstrating construct validity. Health status improved substantially after heart transplant (standardized effect sizes, 0.63–1.24), demonstrating the responsiveness of the PROMIS measures. Scores from the computerized adaptive tests and the short forms were similar. Conclusions: This study provides evidence for the reliability and construct validity (including responsiveness to change) of four PROMIS domains in patients with heart failure before and after heart transplant. PROMIS measures are a reasonable choice in this context and will facilitate comparisons across studies and health conditions.

AB - Purpose: To evaluate the reliability and construct validity of measures from the Patient-Reported Outcomes Measurement Information System® (PROMIS®) for patients with heart failure before and after heart transplantation. Methods: We assessed reliability of the PROMIS short forms using Cronbach’s alpha and the average marginal reliability. To assess the construct validity of PROMIS computerized adaptive tests and short-form measures, we calculated Pearson product moment correlations between PROMIS measures of physical function, fatigue, depression, and social function and existing PRO measures of similar domains (i.e., convergent validity) as well as different domains (i.e., discriminate validity) in patients with heart failure awaiting heart transplant. We evaluated the responsiveness of these measures to change after heart transplant using effect sizes. Results: Forty-eight patients were included in the analyses. Across the many domains examined, correlations between conceptually similar domains were larger than correlations between different domains of health, demonstrating construct validity. Health status improved substantially after heart transplant (standardized effect sizes, 0.63–1.24), demonstrating the responsiveness of the PROMIS measures. Scores from the computerized adaptive tests and the short forms were similar. Conclusions: This study provides evidence for the reliability and construct validity (including responsiveness to change) of four PROMIS domains in patients with heart failure before and after heart transplant. PROMIS measures are a reasonable choice in this context and will facilitate comparisons across studies and health conditions.

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