Introduction and hypothesis: The aims of this study are (1) to assess the reliability (test-retest) of the Urgency Severity and Life Impact Questionnaire (USIQ) and (2) to test the effect of extended-release tolterodine on symptoms of urinary urgency using this validated instrument. Methods: To measure reliability, women with overactive bladder (OAB) completed the USIQ on two separate occasions, prior to treatment for OAB. To assess the responsiveness, the USIQ participants completed the above-mentioned questionnaires prior to and following 4 weeks of treatment for OAB with extended-release tolterodine. Results: USIQ-S and USIQ-QoL scores at the two visits did not differ significantly. Repeated measures of USIQ-S and USIQ-QoL demonstrated a moderate to excellent intraclass correlation coefficient (0.64-0.74; P<0.0001 and 0.48-0.91, P<0.0001, respectively). A significant decrease in mean USIQ-S and USIQ-QOL (71±14 vs. 44±19, P< 0.0001 and 51±22 vs. 39±10, P<0.01, respectively) scores following treatment with tolterodine. Conclusions: This valid, reliable measure can be used in clinical practice and research trials to measure urgency severity.
ASJC Scopus subject areas
- Obstetrics and Gynecology