Reliability and validity of the Functional Assessment of Cancer Therapy-Ovarian

K. Basen-Engquist*, D. Bodurka-Bevers, M. A. Fitzgerald, K. Webster, D. Cella, S. Hu, D. M. Gershenson

*Corresponding author for this work

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Abstract

Purpose: To report the reliability and validity of the Functional Assessment of Cancer Therapy-Ovarian (FACT-O) in a consecutive series of outpatients with epithelial ovarian cancer. Patients and Methods: Two hundred thirty-two ovarian cancer patients attending an outpatient gynecologic oncology clinic completed questionnaires at baseline. The patients' FACT-O scores were compared with their performance status, disease stage, treatment status, and other factors hypothesized to be related to quality of life. Patients received a second questionnaire either one week after baseline to assess the instrument's test-retest reliability and/or two months after baseline to evaluate its sensitivity to change in performance status. Results: Internal consistency and test-retest reliability of the FACT-O were adequate. Overall, the scales correlated with other measures as expected; all correlations were in the hypothesized direction. Patients with advanced disease, poor performance status, and who were receiving active treatment had lower scores on physical, functional, and ovarian cancer-specific scales. The total FACT-O and emotional well-being scores were lower for patients with poor performance status and patients in active treatment. The FACT-O total and all subscale scores except emotional well-being were sensitive to decreases in performance status. Conclusion: Overall, the FACT-O provides a reliable and valid assessment of the quality of life of women with ovarian cancer, and is appropriate as a brief quality of life assessment in clinical trials and descriptive studies.

Original languageEnglish (US)
Pages (from-to)1809-1817
Number of pages9
JournalJournal of Clinical Oncology
Volume19
Issue number6
DOIs
StatePublished - Mar 15 2001

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Basen-Engquist, K., Bodurka-Bevers, D., Fitzgerald, M. A., Webster, K., Cella, D., Hu, S., & Gershenson, D. M. (2001). Reliability and validity of the Functional Assessment of Cancer Therapy-Ovarian. Journal of Clinical Oncology, 19(6), 1809-1817. https://doi.org/10.1200/JCO.2001.19.6.1809