Reliability and validity of the timpsi for infants with spinal muscular atrophy type i

Kristin J. Krosschell*, Jo Anne MacZulski, Charles Scott, Wendy King, Jill T. Hartman, Laura E. Case, Donata Viazzo-Trussell, Janine Wood, Carolyn A. Roman, Eva Hecker, Marianne Meffert, Maude Léveillé, Krista Kienitz, Kathryn J. Swoboda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Purpose: This study examined the reliability and validity of the Test of Infant Motor Performance Screening Items (TIMPSI) in infants with type I spinal muscular atrophy (SMA). Methods: After training, 12 evaluators scored 4 videos of infants with type I SMA to assess interrater reliability. Intrarater and test-retest reliability was further assessed for 9 evaluators during a SMA type I clinical trial, with 9 evaluators testing a total of 38 infants twice. Relatedness of the TIMPSI score to ability to reach and ventilatory support was also examined. Results: Excellent interrater video score reliability was noted (intraclass correlation coefficient, 0.97-0.98). Intrarater reliability was excellent (intraclass correlation coefficient, 0.91-0.98) and test-retest reliability ranged from r = 0.82 to r = 0.95. The TIMPSI score was related to the ability to reach (P ≤.05). Conclusion: The TIMPSI can reliably be used to assess motor function in infants with type I SMA. In addition, the TIMPSI scores are related to the ability to reach, an important functional skill in children with type I SMA.

Original languageEnglish (US)
Pages (from-to)140-148
Number of pages9
JournalPediatric Physical Therapy
Issue number2
StatePublished - Jun 2013


  • Child development
  • Female
  • Humans
  • Infant
  • Male
  • Motor skills/physiology
  • Observer variation
  • Physical therapy specialty/instrumentation
  • Physical therapy specialty/standards
  • Reproducibility of results
  • Spinal muscular atrophies of childhood/diagnosis
  • Spinal muscular atrophies of childhood/physiopathology
  • Video recording

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Pediatrics, Perinatology, and Child Health


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