@article{9fad0a861df14ea9b02a52882fa4d721,
title = "Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment",
abstract = "Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication–compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (PAD = 0.0034) and its ability to study impact of topical treatments on skin diseases.",
author = "Madhvapathy, {Surabhi R.} and Heling Wang and Jessy Kong and Michael Zhang and Lee, {Jong Yoon} and Park, {Jun Bin} and Hokyung Jang and Zhaoqian Xie and Jingyue Cao and Raudel Avila and Chen Wei and Vincent D{\textquoteright}Angelo and Jason Zhu and Chung, {Ha Uk} and Sarah Coughlin and Manish Patel and Joshua Winograd and Jaeman Lim and Anthony Banks and Shuai Xu and Yonggang Huang and Rogers, {John A.}",
note = "Funding Information: S.R.M. acknowledges support from the NSF Graduate Research Fellowship (NSF DGE-1842165). Z.X. acknowledges support from the National Natural Science Foundation of China [grant no. 12072057] and the Fundamental Research Funds for the Central Universities [grant no. DUT20RC(3)032]. R.A. acknowledges support from the NSF Graduate Research Fellowship (NSF DGE-1842165) and Ford Foundation Predoctoral Fellowship. Y.H. acknowledges support from the NSF (CMMI1635443). This work used the Northwestern University Micro/Nano Fabrication Facility (NUFAB), which is partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (DMR-1720139), the State of Illinois, and Northwestern University. Publisher Copyright: Copyright {\textcopyright} 2020 The Authors, some rights reserved.",
year = "2020",
month = dec,
day = "4",
doi = "10.1126/sciadv.abd7146",
language = "English (US)",
volume = "6",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "49",
}