Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment

Surabhi R. Madhvapathy; Heling Wang; Jessy Kong; Michael Zhang; Jong Yoon Lee; Jun Bin Park; Hokyung Jang; Zhaoqian Xie; Jingyue Cao; Raudel Avila; Chen Wei; Vincent D’Angelo; Jason Zhu; Ha Uk Chung; Sarah Coughlin; Manish Patel; Joshua Winograd; Jaeman Lim; Anthony Banks; Shuai Xu; Yonggang Huang; John A. Rogers

doi:10.1126/sciadv.abd7146

Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment

Surabhi R. Madhvapathy, Heling Wang, Jessy Kong, Michael Zhang, Jong Yoon Lee, Jun Bin Park, Hokyung Jang, Zhaoqian Xie, Jingyue Cao, Raudel Avila, Chen Wei, Vincent D’Angelo, Jason Zhu, Ha Uk Chung, Sarah Coughlin, Manish Patel, Joshua Winograd, Jaeman Lim, Anthony Banks, Shuai Xu^*Yonggang Huang, John A. Rogers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication–compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (P_AD = 0.0034) and its ability to study impact of topical treatments on skin diseases.

Original language	English (US)
Article number	eabd7146
Journal	Science Advances
Volume	6
Issue number	49
DOIs	https://doi.org/10.1126/sciadv.abd7146
State	Published - Dec 4 2020

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Madhvapathy, S. R., Wang, H., Kong, J., Zhang, M., Lee, J. Y., Park, J. B., Jang, H., Xie, Z., Cao, J., Avila, R., Wei, C., D’Angelo, V., Zhu, J., Chung, H. U., Coughlin, S., Patel, M., Winograd, J., Lim, J., Banks, A., ... Rogers, J. A. (2020). Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment. Science Advances, 6(49), [eabd7146]. https://doi.org/10.1126/sciadv.abd7146

Madhvapathy, Surabhi R. ; Wang, Heling ; Kong, Jessy ; Zhang, Michael ; Lee, Jong Yoon ; Park, Jun Bin ; Jang, Hokyung ; Xie, Zhaoqian ; Cao, Jingyue ; Avila, Raudel ; Wei, Chen ; D’Angelo, Vincent ; Zhu, Jason ; Chung, Ha Uk ; Coughlin, Sarah ; Patel, Manish ; Winograd, Joshua ; Lim, Jaeman ; Banks, Anthony ; Xu, Shuai ; Huang, Yonggang ; Rogers, John A. / Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment. In: Science Advances. 2020 ; Vol. 6, No. 49.

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title = "Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment",

abstract = "Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication–compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (PAD = 0.0034) and its ability to study impact of topical treatments on skin diseases.",

author = "Madhvapathy, {Surabhi R.} and Heling Wang and Jessy Kong and Michael Zhang and Lee, {Jong Yoon} and Park, {Jun Bin} and Hokyung Jang and Zhaoqian Xie and Jingyue Cao and Raudel Avila and Chen Wei and Vincent D{\textquoteright}Angelo and Jason Zhu and Chung, {Ha Uk} and Sarah Coughlin and Manish Patel and Joshua Winograd and Jaeman Lim and Anthony Banks and Shuai Xu and Yonggang Huang and Rogers, {John A.}",

note = "Funding Information: S.R.M. acknowledges support from the NSF Graduate Research Fellowship (NSF DGE-1842165). Z.X. acknowledges support from the National Natural Science Foundation of China [grant no. 12072057] and the Fundamental Research Funds for the Central Universities [grant no. DUT20RC(3)032]. R.A. acknowledges support from the NSF Graduate Research Fellowship (NSF DGE-1842165) and Ford Foundation Predoctoral Fellowship. Y.H. acknowledges support from the NSF (CMMI1635443). This work used the Northwestern University Micro/Nano Fabrication Facility (NUFAB), which is partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (DMR-1720139), the State of Illinois, and Northwestern University.",

year = "2020",

month = dec,

day = "4",

doi = "10.1126/sciadv.abd7146",

language = "English (US)",

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Madhvapathy, SR, Wang, H, Kong, J, Zhang, M, Lee, JY, Park, JB, Jang, H, Xie, Z, Cao, J, Avila, R, Wei, C, D’Angelo, V, Zhu, J, Chung, HU, Coughlin, S, Patel, M, Winograd, J, Lim, J, Banks, A, Xu, S, Huang, Y & Rogers, JA 2020, 'Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment', Science Advances, vol. 6, no. 49, eabd7146. https://doi.org/10.1126/sciadv.abd7146

Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment. / Madhvapathy, Surabhi R.; Wang, Heling; Kong, Jessy; Zhang, Michael; Lee, Jong Yoon; Park, Jun Bin; Jang, Hokyung; Xie, Zhaoqian; Cao, Jingyue; Avila, Raudel; Wei, Chen; D’Angelo, Vincent; Zhu, Jason; Chung, Ha Uk; Coughlin, Sarah; Patel, Manish; Winograd, Joshua; Lim, Jaeman; Banks, Anthony; Xu, Shuai; Huang, Yonggang; Rogers, John A.

In: Science Advances, Vol. 6, No. 49, eabd7146, 04.12.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Reliable, low-cost, fully integrated hydration sensors for monitoring and diagnosis of inflammatory skin diseases in any environment

AU - Madhvapathy, Surabhi R.

AU - Wang, Heling

AU - Kong, Jessy

AU - Zhang, Michael

AU - Lee, Jong Yoon

AU - Park, Jun Bin

AU - Jang, Hokyung

AU - Xie, Zhaoqian

AU - Cao, Jingyue

AU - Avila, Raudel

AU - Wei, Chen

AU - D’Angelo, Vincent

AU - Zhu, Jason

AU - Chung, Ha Uk

AU - Coughlin, Sarah

AU - Patel, Manish

AU - Winograd, Joshua

AU - Lim, Jaeman

AU - Banks, Anthony

AU - Xu, Shuai

AU - Huang, Yonggang

AU - Rogers, John A.

N1 - Funding Information: S.R.M. acknowledges support from the NSF Graduate Research Fellowship (NSF DGE-1842165). Z.X. acknowledges support from the National Natural Science Foundation of China [grant no. 12072057] and the Fundamental Research Funds for the Central Universities [grant no. DUT20RC(3)032]. R.A. acknowledges support from the NSF Graduate Research Fellowship (NSF DGE-1842165) and Ford Foundation Predoctoral Fellowship. Y.H. acknowledges support from the NSF (CMMI1635443). This work used the Northwestern University Micro/Nano Fabrication Facility (NUFAB), which is partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (DMR-1720139), the State of Illinois, and Northwestern University.

PY - 2020/12/4

Y1 - 2020/12/4

N2 - Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication–compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (PAD = 0.0034) and its ability to study impact of topical treatments on skin diseases.

AB - Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication–compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (PAD = 0.0034) and its ability to study impact of topical treatments on skin diseases.

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