REM behaviour disorder and neurodegenerative diseases

Stefano Zanigni; Giovanna Calandra-Buonaura; Daniela Grimaldi; Pietro Cortelli

doi:10.1016/j.sleep.2011.10.012

REM behaviour disorder and neurodegenerative diseases

Stefano Zanigni, Giovanna Calandra-Buonaura, Daniela Grimaldi, Pietro Cortelli^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Rapid-eye movement (REM) sleep behaviour disorder (RBD) is an REM sleep parasomnia characterized by enactment of dream content during REM sleep associated with loss of muscle atonia. RBD can be either idiopathic or secondary to drugs or other diseases. The best recognized association is with neurodegenerative diseases, namely alpha-synucleinopathies. RBD may represent the first feature of neurodegeneration and can be considered an early marker of these disorders. This review describes the main clinical, pathogenetic, and therapeutic features of RBD, pointing to its association with neurodegenerative diseases and emphasizing the clinical and prognostic implications.

Original language	English (US)
Pages (from-to)	S54-S58
Journal	Sleep Medicine
Volume	12
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/j.sleep.2011.10.012
State	Published - Dec 2011

Keywords

Dementia
Neurodegenerative
Parasomnias
Parkinson
Parkinsonism
REM behaviour disorder
REM sleep

ASJC Scopus subject areas

Medicine(all)

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10.1016/j.sleep.2011.10.012

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abstract = "Rapid-eye movement (REM) sleep behaviour disorder (RBD) is an REM sleep parasomnia characterized by enactment of dream content during REM sleep associated with loss of muscle atonia. RBD can be either idiopathic or secondary to drugs or other diseases. The best recognized association is with neurodegenerative diseases, namely alpha-synucleinopathies. RBD may represent the first feature of neurodegeneration and can be considered an early marker of these disorders. This review describes the main clinical, pathogenetic, and therapeutic features of RBD, pointing to its association with neurodegenerative diseases and emphasizing the clinical and prognostic implications.",

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AU - Zanigni, Stefano

AU - Calandra-Buonaura, Giovanna

AU - Grimaldi, Daniela

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AB - Rapid-eye movement (REM) sleep behaviour disorder (RBD) is an REM sleep parasomnia characterized by enactment of dream content during REM sleep associated with loss of muscle atonia. RBD can be either idiopathic or secondary to drugs or other diseases. The best recognized association is with neurodegenerative diseases, namely alpha-synucleinopathies. RBD may represent the first feature of neurodegeneration and can be considered an early marker of these disorders. This review describes the main clinical, pathogenetic, and therapeutic features of RBD, pointing to its association with neurodegenerative diseases and emphasizing the clinical and prognostic implications.

KW - Dementia

KW - Neurodegenerative

KW - Parasomnias

KW - Parkinson

KW - Parkinsonism

KW - REM behaviour disorder

KW - REM sleep

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REM behaviour disorder and neurodegenerative diseases

Abstract

Keywords

ASJC Scopus subject areas

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