REM sleep deprivation induces galanin gene expression in the rat brain

Jussi Toppila, Dag Stenberg, Lauri Alanko, Marjut Asikainen, Janice H. Urban, Fred W. Turek, Tarja Porkka-Heiskanen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Rats were deprived of REM sleep for 24 h by keeping them on small platforms that were placed in a water bath (the platform method). Galanin coding mRNA was visualized using in situ hybridization, and cells expressing galanin mRNA were counted. In REM sleep-deprived animals the cell count was higher in the preoptic area and periventricular nucleus. Lesions of this area have been reported to induce wakefulness in cats and rats. Galanin administered into the lateral ventricle had no effect on sleep. We conclude that REM sleep deprivation can induce galanin gene expression in some brain areas, but galanin alone does not modify spontaneous sleep.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalNeuroscience Letters
Volume183
Issue number3
DOIs
StatePublished - Jan 9 1995

Keywords

  • Galanin
  • REM sleep
  • Rat
  • Sleep
  • Sleep deprivation

ASJC Scopus subject areas

  • Neuroscience(all)

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