REM sleep deprivation induces galanin gene expression in the rat brain

Jussi Toppila; Dag Stenberg; Lauri Alanko; Marjut Asikainen; Janice H. Urban; Fred W. Turek; Tarja Porkka-Heiskanen

doi:10.1016/0304-3940(94)11143-7

REM sleep deprivation induces galanin gene expression in the rat brain

Jussi Toppila, Dag Stenberg, Lauri Alanko, Marjut Asikainen, Janice H. Urban, Fred W. Turek, Tarja Porkka-Heiskanen^*

^*Corresponding author for this work

Neurobiology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Rats were deprived of REM sleep for 24 h by keeping them on small platforms that were placed in a water bath (the platform method). Galanin coding mRNA was visualized using in situ hybridization, and cells expressing galanin mRNA were counted. In REM sleep-deprived animals the cell count was higher in the preoptic area and periventricular nucleus. Lesions of this area have been reported to induce wakefulness in cats and rats. Galanin administered into the lateral ventricle had no effect on sleep. We conclude that REM sleep deprivation can induce galanin gene expression in some brain areas, but galanin alone does not modify spontaneous sleep.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	Neuroscience Letters
Volume	183
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(94)11143-7
State	Published - Jan 9 1995

Keywords

Galanin
REM sleep
Rat
Sleep
Sleep deprivation

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)11143-7

Cite this

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title = "REM sleep deprivation induces galanin gene expression in the rat brain",

abstract = "Rats were deprived of REM sleep for 24 h by keeping them on small platforms that were placed in a water bath (the platform method). Galanin coding mRNA was visualized using in situ hybridization, and cells expressing galanin mRNA were counted. In REM sleep-deprived animals the cell count was higher in the preoptic area and periventricular nucleus. Lesions of this area have been reported to induce wakefulness in cats and rats. Galanin administered into the lateral ventricle had no effect on sleep. We conclude that REM sleep deprivation can induce galanin gene expression in some brain areas, but galanin alone does not modify spontaneous sleep.",

keywords = "Galanin, REM sleep, Rat, Sleep, Sleep deprivation",

author = "Jussi Toppila and Dag Stenberg and Lauri Alanko and Marjut Asikainen and Urban, {Janice H.} and Turek, {Fred W.} and Tarja Porkka-Heiskanen",

note = "Funding Information: This work was supported by the Paulo Foundation.",

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T1 - REM sleep deprivation induces galanin gene expression in the rat brain

AU - Toppila, Jussi

AU - Stenberg, Dag

AU - Alanko, Lauri

AU - Asikainen, Marjut

AU - Urban, Janice H.

AU - Turek, Fred W.

AU - Porkka-Heiskanen, Tarja

N1 - Funding Information: This work was supported by the Paulo Foundation.

PY - 1995/1/9

Y1 - 1995/1/9

N2 - Rats were deprived of REM sleep for 24 h by keeping them on small platforms that were placed in a water bath (the platform method). Galanin coding mRNA was visualized using in situ hybridization, and cells expressing galanin mRNA were counted. In REM sleep-deprived animals the cell count was higher in the preoptic area and periventricular nucleus. Lesions of this area have been reported to induce wakefulness in cats and rats. Galanin administered into the lateral ventricle had no effect on sleep. We conclude that REM sleep deprivation can induce galanin gene expression in some brain areas, but galanin alone does not modify spontaneous sleep.

AB - Rats were deprived of REM sleep for 24 h by keeping them on small platforms that were placed in a water bath (the platform method). Galanin coding mRNA was visualized using in situ hybridization, and cells expressing galanin mRNA were counted. In REM sleep-deprived animals the cell count was higher in the preoptic area and periventricular nucleus. Lesions of this area have been reported to induce wakefulness in cats and rats. Galanin administered into the lateral ventricle had no effect on sleep. We conclude that REM sleep deprivation can induce galanin gene expression in some brain areas, but galanin alone does not modify spontaneous sleep.

KW - Galanin

KW - REM sleep

KW - Rat

KW - Sleep

KW - Sleep deprivation

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REM sleep deprivation induces galanin gene expression in the rat brain

Abstract

Keywords

ASJC Scopus subject areas

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