Remarkably stable tetrahedral intermediates: Carbinols from nucleophilic additions to N-acylpyrroles

David A. Evans*, George Borg, Karl A. Scheidt

*Corresponding author for this work

Research output: Contribution to journalArticle

140 Scopus citations

Abstract

Sufficiently stable intermediates formed in the reaction of N-acylpyrroles (1) with hydride and Grignard reagents can undergo further synthetic transformations and chromatographic purification to enable the generation of pyrrolecarbinols 2 in 76-95% yields [Eq. (1)].

Original languageEnglish (US)
Pages (from-to)3188-3191
Number of pages4
JournalAngewandte Chemie - International Edition
Volume41
Issue number17
DOIs
StatePublished - Sep 2 2002

Keywords

  • Carbinols
  • Nitrogen heterocycles
  • Nucleophilic addition
  • Reaction intermediates
  • Reaction mechanisms

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Remarkably stable tetrahedral intermediates: Carbinols from nucleophilic additions to N-acylpyrroles'. Together they form a unique fingerprint.

  • Cite this