Remodeling of calcium handling in human heart failure

Qing Lou, Ajit Janardhan, Igor R. Efimov*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

69 Scopus citations

Abstract

Heart failure (HF) is an increasing public health problem accelerated by a rapidly aging global population. Despite considerable progress in managing the disease, the development of new therapies for effective treatment of HF remains a challenge. To identify targets for early diagnosis and therapeutic intervention, it is essential to understand the molecular and cellular basis of calcium handling and the signaling pathways governing the functional remodeling associated with HF in humans. Calcium (Ca 2+) cycling is an essential mediator of cardiac contractile function, and remodeling of calcium handling is thought to be one of the major factors contributing to the mechanical and electrical dysfunction observed in HF. Active research in this field aims to bridge the gap between basic research and effective clinical treatments of HF. This chapter reviews the most relevant studies of calcium remodeling in failing human hearts and discusses their connections to current and emerging clinical therapies for HF patients.

Original languageEnglish (US)
Title of host publicationCalcium Signaling
Pages1145-1174
Number of pages30
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume740
ISSN (Print)0065-2598

Keywords

  • Calcium
  • Clinical treatment
  • Heart failure
  • Human
  • Remodeling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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