Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment

Mengwei Chen, Jiaojiao Wu, Peng Ning, Jingjing Wang, Zuan Ma, Liqun Huang, Gustavo R. Plaza, Yajing Shen, Chang Xu, Yu Han, Maciej S. Lesniak*, Zhongmin Liu, Yu Cheng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep-seated tumors in a spatiotemporal fashion.

Original languageEnglish (US)
Article number1905424
JournalSmall
Volume16
Issue number3
DOIs
StatePublished - Jan 1 2020

Keywords

  • apoptosis
  • cancer
  • magnetic nanocubes
  • magnetomechanical destruction
  • mitochondrial

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

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