Renal artery stenosis in swine: Feasibility of MR assessment of renal function during percutaneous transluminal angioplasty

Jonathan K. Park; Thomas K. Rhee; Ty A. Cashen; Wanyong Shin; Brian E. Schirf; James A. Gehl; Andrew C. Larson; Pottumarthi V. Prasad; Debiao Li; Timothy J. Carroll; Reed A. Omary

doi:10.1148/radiol.2433060184

Renal artery stenosis in swine: Feasibility of MR assessment of renal function during percutaneous transluminal angioplasty

Jonathan K. Park, Thomas K. Rhee, Ty A. Cashen, Wanyong Shin, Brian E. Schirf, James A. Gehl, Andrew C. Larson, Pottumarthi V. Prasad, Debiao Li, Timothy J. Carroll, Reed A. Omary^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Purpose: To prospectively test - in a swine model of renal artery stenosis (RAS) - the hypothesis that magnetic resonance (MR) imaging can reveal changes in renal function at the time of percutaneous transluminal angioplasty (PTA). Materials and Methods: In this animal care and use committee-approved study, high-grade unilateral RAS was surgically induced in six pigs. MR imaging at 3.0 T was used for intraprocedural assessment of the anatomic and physiologic changes induced by x-ray-guided PTA. With use of MR imaging, changes in single-kidney glomerular filtration rate, extraction fraction, and renal blood flow were assessed during PTA. The arterial diameter of stenosis before and after PTA was assessed by using conventional digital subtraction angiography. Mean changes in functional and anatomic parameters were compared by using the Wilcoxon signed rank test (α = .05). Results: At digital subtraction angiography, the mean percentage of stenosis was 69% ± 10 (standard deviation) before PTA and 26% ± 10 after PTA (P < .03). Mean pre- and post-PTA extraction fraction values were 0.11 ± 0.03 and 0.19 ± 0.06, respectively (P < .03). The mean single-kidney glomerular filtration rate before PTA, 19 mL/min ± 13, increased to 41 mL/min ± 33 after PTA (P < .03). There was no significant change in mean renal blood flow after PTA (P = .44). Conclusion: In swine, MR imaging can reveal changes in renal function after x-ray-guided PTA for unilateral RAS.

Original language	English (US)
Pages (from-to)	144-150
Number of pages	7
Journal	Radiology
Volume	244
Issue number	1
DOIs	https://doi.org/10.1148/radiol.2433060184
State	Published - Jul 2007

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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@article{f4abd0c5a6f34e38802df0be1b93f073,

title = "Renal artery stenosis in swine: Feasibility of MR assessment of renal function during percutaneous transluminal angioplasty",

abstract = "Purpose: To prospectively test - in a swine model of renal artery stenosis (RAS) - the hypothesis that magnetic resonance (MR) imaging can reveal changes in renal function at the time of percutaneous transluminal angioplasty (PTA). Materials and Methods: In this animal care and use committee-approved study, high-grade unilateral RAS was surgically induced in six pigs. MR imaging at 3.0 T was used for intraprocedural assessment of the anatomic and physiologic changes induced by x-ray-guided PTA. With use of MR imaging, changes in single-kidney glomerular filtration rate, extraction fraction, and renal blood flow were assessed during PTA. The arterial diameter of stenosis before and after PTA was assessed by using conventional digital subtraction angiography. Mean changes in functional and anatomic parameters were compared by using the Wilcoxon signed rank test (α = .05). Results: At digital subtraction angiography, the mean percentage of stenosis was 69% ± 10 (standard deviation) before PTA and 26% ± 10 after PTA (P < .03). Mean pre- and post-PTA extraction fraction values were 0.11 ± 0.03 and 0.19 ± 0.06, respectively (P < .03). The mean single-kidney glomerular filtration rate before PTA, 19 mL/min ± 13, increased to 41 mL/min ± 33 after PTA (P < .03). There was no significant change in mean renal blood flow after PTA (P = .44). Conclusion: In swine, MR imaging can reveal changes in renal function after x-ray-guided PTA for unilateral RAS.",

author = "Park, {Jonathan K.} and Rhee, {Thomas K.} and Cashen, {Ty A.} and Wanyong Shin and Schirf, {Brian E.} and Gehl, {James A.} and Larson, {Andrew C.} and Prasad, {Pottumarthi V.} and Debiao Li and Carroll, {Timothy J.} and Omary, {Reed A.}",

year = "2007",

month = jul,

doi = "10.1148/radiol.2433060184",

language = "English (US)",

volume = "244",

pages = "144--150",

journal = "Radiology",

issn = "0033-8419",

publisher = "Radiological Society of North America Inc.",

number = "1",

}

TY - JOUR

T1 - Renal artery stenosis in swine

T2 - Feasibility of MR assessment of renal function during percutaneous transluminal angioplasty

AU - Park, Jonathan K.

AU - Rhee, Thomas K.

AU - Cashen, Ty A.

AU - Shin, Wanyong

AU - Schirf, Brian E.

AU - Gehl, James A.

AU - Larson, Andrew C.

AU - Prasad, Pottumarthi V.

AU - Li, Debiao

AU - Carroll, Timothy J.

AU - Omary, Reed A.

PY - 2007/7

Y1 - 2007/7

N2 - Purpose: To prospectively test - in a swine model of renal artery stenosis (RAS) - the hypothesis that magnetic resonance (MR) imaging can reveal changes in renal function at the time of percutaneous transluminal angioplasty (PTA). Materials and Methods: In this animal care and use committee-approved study, high-grade unilateral RAS was surgically induced in six pigs. MR imaging at 3.0 T was used for intraprocedural assessment of the anatomic and physiologic changes induced by x-ray-guided PTA. With use of MR imaging, changes in single-kidney glomerular filtration rate, extraction fraction, and renal blood flow were assessed during PTA. The arterial diameter of stenosis before and after PTA was assessed by using conventional digital subtraction angiography. Mean changes in functional and anatomic parameters were compared by using the Wilcoxon signed rank test (α = .05). Results: At digital subtraction angiography, the mean percentage of stenosis was 69% ± 10 (standard deviation) before PTA and 26% ± 10 after PTA (P < .03). Mean pre- and post-PTA extraction fraction values were 0.11 ± 0.03 and 0.19 ± 0.06, respectively (P < .03). The mean single-kidney glomerular filtration rate before PTA, 19 mL/min ± 13, increased to 41 mL/min ± 33 after PTA (P < .03). There was no significant change in mean renal blood flow after PTA (P = .44). Conclusion: In swine, MR imaging can reveal changes in renal function after x-ray-guided PTA for unilateral RAS.

AB - Purpose: To prospectively test - in a swine model of renal artery stenosis (RAS) - the hypothesis that magnetic resonance (MR) imaging can reveal changes in renal function at the time of percutaneous transluminal angioplasty (PTA). Materials and Methods: In this animal care and use committee-approved study, high-grade unilateral RAS was surgically induced in six pigs. MR imaging at 3.0 T was used for intraprocedural assessment of the anatomic and physiologic changes induced by x-ray-guided PTA. With use of MR imaging, changes in single-kidney glomerular filtration rate, extraction fraction, and renal blood flow were assessed during PTA. The arterial diameter of stenosis before and after PTA was assessed by using conventional digital subtraction angiography. Mean changes in functional and anatomic parameters were compared by using the Wilcoxon signed rank test (α = .05). Results: At digital subtraction angiography, the mean percentage of stenosis was 69% ± 10 (standard deviation) before PTA and 26% ± 10 after PTA (P < .03). Mean pre- and post-PTA extraction fraction values were 0.11 ± 0.03 and 0.19 ± 0.06, respectively (P < .03). The mean single-kidney glomerular filtration rate before PTA, 19 mL/min ± 13, increased to 41 mL/min ± 33 after PTA (P < .03). There was no significant change in mean renal blood flow after PTA (P = .44). Conclusion: In swine, MR imaging can reveal changes in renal function after x-ray-guided PTA for unilateral RAS.

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DO - 10.1148/radiol.2433060184

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AN - SCOPUS:34250806075

SN - 0033-8419

VL - 244

SP - 144

EP - 150

JO - Radiology

JF - Radiology

IS - 1

ER -

Renal artery stenosis in swine: Feasibility of MR assessment of renal function during percutaneous transluminal angioplasty

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