Renal function 9 to 17 years after childhood lead poisoning

Donald I. Moel*, Henrietta K. Sachs, Richard A Cohn, Mary Ann Drayton

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Renal function was studied in 74 subjects who, between 1966 and 1972 (ages 1 to 6 years) had had blood lead levels (PbB) ≥100 μg/dl (range 100 to 471 μg/dl, median 142 μg/dl) and in 21 sibling controls. PbB measured in 1983 in study subjects remained significantly higher than in sibling controls (mean ± 1 SD 14.5 ± 4.5 vs 11.6 ± 2.6 μg/dl, P<0.01). The two groups did not differ in development of hematuria or leukocyturia. The frequency of elevated serum creatinine concentration, depressed creatinine clearance, elevated protein excretion, low urinary osmolality, elevated serum β2-microglobulin (β2-M), and elevated fractional excretion β2-M %×100 was similar in the two groups. Mean values for these tests were similar in study subjects compared with sibling controls. Mean systolic blood pressure was significantly higher in study subjects compared with that in sibling controls (117±12 vs 109±10 mm Hg), but the control group contained a preponderance of females and the study group had more overweight females; mean diastolic blood pressure was similar in the two groups. We conclude that in our adolescent subjects who had had lead poisoning 9 to 17 years earlier, there is little if any evidence of chronic nephropathy.

Original languageEnglish (US)
Pages (from-to)729-733
Number of pages5
JournalThe Journal of Pediatrics
Volume106
Issue number5
DOIs
StatePublished - Jan 1 1985

Fingerprint

Lead Poisoning
Siblings
Blood Pressure
Kidney
Creatinine
Hematuria
Serum
Osmolar Concentration
Control Groups
Proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Moel, Donald I. ; Sachs, Henrietta K. ; Cohn, Richard A ; Drayton, Mary Ann. / Renal function 9 to 17 years after childhood lead poisoning. In: The Journal of Pediatrics. 1985 ; Vol. 106, No. 5. pp. 729-733.
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Renal function 9 to 17 years after childhood lead poisoning. / Moel, Donald I.; Sachs, Henrietta K.; Cohn, Richard A; Drayton, Mary Ann.

In: The Journal of Pediatrics, Vol. 106, No. 5, 01.01.1985, p. 729-733.

Research output: Contribution to journalArticle

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