Renal morphologic lesions reminiscent of diabetic nephropathy

Kirtee Raparia, Irtaza Usman, Yashpal S. Kanwar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Context. - Nodular, intercapillary glomerulosclerotic lesions resembling Kimmelstiel-Wilson nodules commonly observed in diabetic nephropathy can also be seen in patients without any clinical history or evidence of diabetes. Objectives. - To discuss the pathobiology of lesions reminiscent of diabetes nephropathy, including light-chain deposition disease, amyloidosis, immunotactoid nephropathy, the membranoproliferative form of glomerulonephritis, and idiopathic nodular glomerulosclerosis, and how to differentiate them from diabetic nephropathy. Data Sources. - Published literature and authors' personal experience. Conclusions. - The well-formed, intercapillary, nodular mesangial lesions, along with thickened glomerular basement membranes and tubular basement membranes, and hyaline arteriolosclerosis are virtually pathognomic of diabetic nephropathy. However, the pathologist must exclude lesions reminiscent of diabetic nephropathy by performing special stains on histologic sections, immunofluorescence, and electron microscopic studies.

Original languageEnglish (US)
Pages (from-to)351-359
Number of pages9
JournalArchives of Pathology and Laboratory Medicine
Issue number3
StatePublished - Mar 2013

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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