Abstract
Renal osteodystrophy (ROD) associated with chronic kidney disease (CKD) involves a complex interrelationship of the loss of divalent mineral homeostasis, hyperparathyroidism, and gene modulation. In affected children, ROD leads to impaired linear growth as well as to the development of other significant skeletal and extraskeletal manifestations. Despite the success of kidney transplantation, many ROD complications cannot be completely reversed; and thus, patients with CKD and ROD require long-term follow-up. Although the availability of vitamin D analogues has advanced ROD management, it has also created new issues for clinicians to address, motivating future investigations of calcimimetic therapies. An algorithmic approach to the management of ROD in children is presented; to be most effective, this approach requires close and frequent surveillance to prevent side effects related to potent therapies.
Original language | English (US) |
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Pages (from-to) | 42-47 |
Number of pages | 6 |
Journal | Growth Hormone and IGF Research |
Volume | 15 |
Issue number | SUPPL. |
DOIs | |
State | Published - Jul 2005 |
Funding
This work was supported in part by a Grant for Excellence in Academic Medicine from the Illinois Department of Public Health, and from the support of the Zell Family Foundation and James J. and Jamie Thorsen McNulty Family Foundation.
Keywords
- Calcium
- Growth disorder
- Growth hormone
- Phosphorus
- Secondary hyperparathyroidism
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism